Prognostic role of histological necrosis for nonmetastatic clear cell renal cell carcinoma: correlation with pathological features and molecular markers

The Journal of Urology
Andrea MinerviniMarco Carini

Abstract

We defined the prognostic role of tumor necrosis and its extent in nonmetastatic clear cell renal cell carcinoma. Also, we further investigated its pathogenesis by correlating this tumor feature with other pathological characteristics and molecular markers related to the von Hippel Lindau-hypoxia inducible factor pathway and to tumor proliferation. A total of 213 patients with nonmetastatic clear cell renal cell carcinoma were evaluated. Mean followup was 66 months. The presence and extent of histological necrosis were correlated with clinicopathological factors, Ki-67 antigen expression calculated by the MIB-1 (Ki-67 antibody) index, pVHL, HIF-1alpha, the tumor infiltrating lymphocyte subset and cancer specific survival. Histological necrosis was present in 63.8% of clear cell renal cell carcinoma cases. Necrosis was significantly associated with grade and the degree of tumor infiltrating lymphocytes, while its extent correlated significantly with grade, the degree of tumor infiltrating lymphocytes and stage. Tumor necrosis was a significant prognostic factor, which was confirmed even when limiting analysis to patients with intracapsular renal cell carcinoma. On multivariate analysis histological necrosis was not an independen...Continue Reading

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Citations

Apr 30, 2013·Journal of Cancer Research and Clinical Oncology·Raoul A DroeserGad Singer
Jan 21, 2012·American Journal of Clinical Pathology·Martin PichlerRichard Zigeuner
Jan 20, 2010·The Journal of Urology·Matthew D KatzAdam S Kibel
Sep 29, 2009·Urology·Hendrik IsbarnPierre I Karakiewicz
Mar 6, 2009·The Lancet Oncology·Sushanth Reddy, Christopher L Wolfgang
Apr 30, 2009·Cancer·Chao-Nan QianBin Tean Teh
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Feb 23, 2012·Rare Tumors·Mohamed A ZayedSherry M Wren
Mar 1, 2011·The Kaohsiung Journal of Medical Sciences·Ying-Hsu ChangShuen-Kuei Liao
May 15, 2021·The British Journal of Radiology·Qingqiang ZhuJing Ye
Oct 14, 2021·American Journal of Clinical Pathology·Madiha SyedUsman Hassan

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