Prognostic Role of Histological Tumor Regression in Patients Receiving Neoadjuvant Chemotherapy for High-Grade Serous Tubo-ovarian Carcinoma

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Edwina CoghlanPaul A Cohen

Abstract

Our objective was to validate the prognostic role of the chemotherapy response score (CRS), which has been proposed for measuring tumor response to neoadjuvant chemotherapy in patients with high-grade serous tubo-ovarian carcinoma, in predicting progression-free survival (PFS) and overall survival (OS). A retrospective cohort study was conducted of patients with advanced high-grade serous tubo-ovarian carcinoma diagnosed between January 1, 2010, and December 31, 2014, and treated with neoadjuvant chemotherapy. Treatment-related tumor regression was determined according to the 3-tier CRS, and results were compared with standard clinicopathological variables. Survival analysis was performed using Cox proportional hazards models and the log-rank test. Seventy-one patients were eligible for analysis. Median OS was 25.5 months. Fifty-eight patients (82%) had disease recurrence and 32 (45%) had died at study census. Of the 71 patients, 19, 29, and 23 patients had a CRS of 1, 2, and 3, respectively. On univariate analysis, the CRS significantly predicted PFS (hazard ratio [HR], 3.77; 95% confidence interval [CI], 1.83-7.78; P = 0.000) and OS (HR, 2.81; 95% CI, 1.16-6.79; P = 0.022). In a multivariate model, the CRS was significantly a...Continue Reading

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Citations

May 8, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Camilla NeroMarco Petrillo
Nov 3, 2020·Critical Reviews in Oncology/hematology·Riccardo Ponzone
May 18, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Meabh McNultyAndrew Dean
Oct 12, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jonathan S BerekMichael Friedlander
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ColomboUNKNOWN ESMO-ESGO Ovarian Cancer Consensus Conference Working Group
Oct 28, 2019·The American Journal of Surgical Pathology·Barrett C LawsonAnais Malpica
Nov 23, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Pier Carlo ZorzatoAnna Fagotti
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Jan 27, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Steffen BöhmNaveena Singh
Sep 9, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Michelle HeaynRohit Bhargava

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