Prognostic Role of Liver Stiffness Measurements Using Magnetic Resonance Elastography in Patients with Compensated Chronic Liver Disease

European Radiology
Dong Ho LeeJoon Koo Han

Abstract

To retrospectively evaluate the prognostic role of liver stiffness (LS) measurement using magnetic resonance elastography (MRE) in patients with compensated chronic liver disease (cCLD). We enrolled 217 patients with cCLD who underwent MRE. After mean follow-up of 45.0 ± 17.6 months, cumulative incidence (CI) of hepatocellular carcinoma (HCC) occurrence, development of decompensation and overall survival (OS) were estimated using the Kaplan-Meier method. Prognostic factors were evaluated using the Cox proportional hazard regression model. During the follow-up period, HCC occurred in 33 patients, and 1-, 3- and 5-year CIs of HCC occurrence were 3.8%, 14.8% and 18.9%, respectively. The LS value was a significant predictive factor for HCC occurrence [p < 0.001, hazard ratio (HR) = 1.59 per unit (1.25-2.03)]. Eighteen patients experienced hepatic decompensation, and 1-, 3- and 5-year CIs of decompensation were 2.8%, 7.3% and 11.3%, respectively. The LS value was also significantly associated with decompensation development [p < 0.001, HR = 2.02 per unit (1.37-2.98)]. Fourteen patients died, and 1-, 3- and 5-year OSs were 99.1%, 98.0% and 89.8%, respectively. The LS value was demonstrated to be a significant affecting factor for OS ...Continue Reading

References

Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·D M ParkinP Pisani
Apr 27, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·David H Van ThielJohn Brems
Feb 12, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Michele ManosBeth P Bell
Mar 11, 2008·Lancet·Detlef Schuppan, Nezam H Afdhal
May 13, 2008·Gastroenterology·Laurent HuwartBernard E Van Beers
Jul 31, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Patrick AsbachIngolf Sack
Jan 16, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoMassimo Pinzani
Oct 6, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nam C YuDavid S K Lu
Nov 6, 2010·Alimentary Pharmacology & Therapeutics·K M FlemingJ West
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kyu Sik JungKwang-Hyub Han
Feb 22, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sohae ChungLeon Axel
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag
Jan 25, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christophe CorpechotRaoul Poupon
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
Jul 7, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanna FerraioliUNKNOWN Liver Fibrosis Study Group
Jul 11, 2012·Journal of Magnetic Resonance Imaging : JMRI·Lorenzo MannelliJeffrey H Maki
Feb 12, 2013·Seminars in Ultrasound, CT, and MR·Edmund M GodfreyDavid J Lomas
Feb 20, 2013·Journal of Hepatology·Martin BlachierFrançoise Roudot-Thoraval
Apr 16, 2013·Gastroenterology·Sumeet K AsraniW Ray Kim
Aug 21, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghJayant A Talwalkar
Oct 17, 2013·Journal of Hepatology·Grace Lai-Hung WongVincent Wai-Sun Wong
Dec 24, 2013·Journal of Hepatology·Sumeet K AsraniRichard L Ehman
Aug 12, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rohit LoombaClaude Sirlin
Dec 3, 2014·Journal of Hepatology·Bernard E Van BeersPhilippe Garteiser
Oct 16, 2015·Clinical Physiology and Functional Imaging·Maja ThieleAleksander Krag
Oct 1, 2016·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Aparna Srinivasa BabuSudhakar K Venkatesh

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Citations

Apr 12, 2019·AJR. American Journal of Roentgenology·Andrew Dennis SmithMark E Lockhart
Nov 30, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Houchun H HuS Sendhil Velan
Feb 19, 2020·Gut·Rohit Loomba, Leon A Adams
Jul 25, 2020·Abdominal Radiology·Ilkay S IdilmanSudhakar K Venkatesh

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