Prognostic role of ΔMTV and ΔTLG in Burkitt lymphoma

Annals of Nuclear Medicine
Domenico AlbanoFrancesco Bertagna

Abstract

Burkitt's lymphoma (BL) is an aggressive lymphoma sub-type with high 18F-FDG avidity, but no well established evidence of PET/CT's role in treatment evaluation or prognosis is currently available. The prognostic role of visual analysis and Deauville criteria for BL have already been demonstrated, while the potential usefulness of semi-quantitative PET/CT features remains unclear, especially the value of the rate of reduction in metabolic tumor volume (MTV) and total lesion glycolysis (TLG). The aim of this retrospective study was to investigate whether ΔMTV and ΔTLG can predict treatment response at the end of therapy and prognosis in BL. We retrospectively included 61 patients (mean age 61; 40 male, 21 female) who underwent baseline, interim and end-of-treatment 18F-FDG PET/CT. The PET/CT images were analyzed visually and semi-quantitatively by measuring total metabolic tumor volume (MTV) and total lesion glycolysis (TLG) for every scan. Then we calculated volume changes based on the percentage of MTV and TLG reduction between the baseline and interim PET (ΔMTVi and ΔTLGi) and between baseline and end-of-treatment PET/CT (ΔMTVeot and ΔTLGeot) and correlated them with clinical response and progression-free survival (PFS) and ov...Continue Reading

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Jul 10, 2018·Annals of Nuclear Medicine·Domenico AlbanoFrancesco Bertagna
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Oct 10, 2018·Hematological Oncology·Domenico AlbanoFrancesco Bertagna
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Citations

Sep 15, 2020·Annals of Nuclear Medicine·Juan Carlos Prieto PrietoChrissa Sioka
Feb 8, 2020·Clinical Lymphoma, Myeloma & Leukemia·Domenico AlbanoFrancesco Bertagna
Jan 18, 2022·British Journal of Haematology·Tarec Christoffer El-GalalyLars C Gormsen

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