Prognostic Role of Neutrophil to Lymphocyte Ratio in Ovarian Cancer: A Meta-Analysis

Technology in Cancer Research & Treatment
Gaowen ChenYifeng Wang

Abstract

The aim of the study was to investigate the prognostic role of neutrophil to lymphocyte ratio in ovarian cancer. Growing number of articles reported the relationship between neutrophil to lymphocyte ratio and prognosis in ovarian cancer, but the results remains inconclusive. The meta-analysis was conducted to analyze the association of pretreatment neutrophil to lymphocyte ratio with overall survival and progression-free survival. We performed a systematic literature research of PubMed, EMBASE, Medline, and Cochrane library for relevant studies up to October 8, 2017. The quality of included studies was assessed by the Newcastle-Ottawa Quality Assessment Scale. The hazard ratio and corresponding 95% confidence intervals were calculated. We checked the heterogeneity by the Q test and Higgins I-squared statistic. Begg funnel plot and Egger linear regression test were also applied for ascertain publication bias. All of the statistical analyses were performed using STATA version 12.0. A total of 12 studies with 4046 patients were included in our study. The results indicated that depressed neutrophil to lymphocyte ratio was significantly correlated with higher overall survival (hazard ratio = 1.409, 95% confidence intervals = 1.112-1...Continue Reading

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Citations

Jul 20, 2019·The Journal of International Medical Research·Yusuf ÇekiciÖzlem Seçen
Dec 20, 2019·Journal of Cancer Research and Clinical Oncology·Alberto PosabellaGad Singer
Sep 29, 2020·Frontiers in Genetics·Ya GuoHeng Luo
Sep 17, 2020·Obstetrics & Gynecology Science·Asami IkedaIkuo Konishi
Sep 19, 2019·Cancer Research·Massimo SainiNicola Aceto
Jan 22, 2021·Seminars in Cancer Biology·Alia GhoneumNeveen Said
Oct 30, 2020·Cancer Management and Research·Razan MansourMaysa Al-Hussaini
Jul 7, 2021·International Journal of Clinical Practice·Juan R Ulloque-BadaraccoAdrian V Hernandez

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Software Mentioned

STATA
Galbraith Plot

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