Prognostic role of neutrophil-to-lymphocyte ratio in diffuse large B cell lymphoma patients: an updated dose-response meta-analysis

Cancer Cell International
Shidai MuYu Hu

Abstract

The neutrophil-to-lymphocyte ratio (NLR), a biomarker for systematic inflammation, has been recently identified as a prognostic factor for various types of both solid and hematologic malignancies. Here we conducted an updated dose-response meta-analysis to investigate whether NLR can be served as a prognostic biomarker in diffuse large B cell lymphoma (DLBCL). We systematically searched PubMed, Embase, ISI Web of Science and CNKI for relevant studies. Odds ratios or hazards ratios (HRs) with corresponding 95% confidence intervals (CIs) were pooled to estimate the association between NLR and clinicopathological parameters or survival of cancer patients. Eleven trials with 2515 DLBCL patients were included in the meta-analysis. The results revealed that elevated pretreatment NLR was significantly associated with elder age, advanced Ann Arbor stage, higher incidence rate of B symptoms and bone marrow involvement, and higher lactate dehydrogenase level, etc. Moreover, increased NLR also predicted poorer overall survival (HR 1.826, 95% CI 1.238-2.692) and progression-free survival/event-free survival (PFS/EFS) (HR 1.591, 95% CI 1.124-2.252). And two-stage dose-response meta-analysis revealed non-linear association between increased ...Continue Reading

References

Jun 21, 2002·The New England Journal of Medicine·Andreas RosenwaldUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
Jun 25, 2009·Cancer Research·Isabelle Ray-CoquardUNKNOWN European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Sep 16, 2010·American Journal of Hematology·Luis F PorrataSvetomir N Markovic
Aug 17, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jonathan W Friedberg
Dec 14, 2011·Hematology·Jonathan W Friedberg
Dec 12, 2012·Journal of Clinical Immunology·Juliana Candido, Thorsten Hagemann
Mar 15, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Vaidya, T E Witzig
May 14, 2014·Advances in Experimental Medicine and Biology·Antonino CarboneAnnunziata Gloghini
May 31, 2014·Journal of the National Cancer Institute·Arnoud J TempletonEitan Amir
Jan 21, 2015·Frontiers in Psychology·Mike W-L Cheung
Dec 15, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Thomas MelchardtAlexander Egle

❮ Previous
Next ❯

Citations

Nov 20, 2019·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Mustafa ÇolakKürşat Murat Özcan
Aug 1, 2020·Journal of Clinical Medicine·Roberto TammaDomenico Ribatti
Nov 29, 2020·Veterinary and Comparative Oncology·Joaquim HenriquesJane Dobson

❮ Previous
Next ❯

Software Mentioned

meta SEM
STATA
R

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.