Prognostic role of nuclear factor/IB and bone remodeling proteins in metastatic giant cell tumor of bone: A retrospective study

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Irene QuattriniMaria Serena Benassi

Abstract

Giant cell tumor of bone (GCTb) represents 5% of bone tumors, and although considered benign, 5% metastasize to the lung. The expression of proteins directly or indirectly associated with osteolysis and tumor growth was studied on 163 samples of GCTb. Of these, 33 patients developed lung metastasis during follow-up. The impact of tumor-host interaction on clinical aspects was evaluated with the aim of finding specific markers for new biological therapies, thus improving clinical management of GCTb. Protein expression was evaluated by immunohistochemical analysis on Tissue Microarray. The majority of GCTb samples from patients with metastatic disease were strongly positive to RANKL and its receptor RANK as well as to CAII and MMP-2 and to pro-survival proteins NFIB and c-Fos. Kaplan-Meier analysis indicated a significant difference in metastasis free survival curves based on protein staining. Interestingly, the statistical correlation established a strong association between all variables studied with a higher τ coefficient for RANK/RANKL, RANK/NFIB, and RANKL/NFIB pairs. At multivariate analysis co-overexpression of NFIB, RANK and RANKL significantly increased the risk of metastasis with an odds ratio of 13.59 (95%CI 4.12-44.82...Continue Reading

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Jun 1, 2012·Journal of Bone Oncology·Dominique Heymann

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Citations

Apr 14, 2016·Future Oncology·Vadim V Maximov, Rami I Aqeilan
Jul 29, 2018·Proteomics. Clinical Applications·Amalia ContiLaura Pazzaglia
May 10, 2018·Japanese Journal of Clinical Oncology·Boris ItkinAriel Bardach
Nov 9, 2020·Journal of Orthopaedic Surgery and Research·Shinji TsukamotoCostantino Errani
Oct 8, 2021·Orthopedics·Shinji TsukamotoCostantino Errani

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