PMID: 8944613Nov 1, 1996Paper

Prognostic role of oestrogen and progesterone receptors in patients with breast cancer: relation to age and lymph node status

Journal of Clinical Pathology
K CollettB O Maehle

Abstract

To consider the prognostic role of oestrogen receptor and progesterone receptor status in relation to the age at surgery, length of follow up and lymph node status. The study population comprised 977 patients with histologically confirmed breast carcinoma, with a median follow up of nine years. The actuarial life table method was used to test for survival differences. The Cox proportional hazard model was used to test for interaction effects between each hormone receptor and age, lymph node status and length of follow up. As the analysis involved multiple subgroups, significance was set at the 1% level (p < 0.01). When the patients were subdivided into groups according to lymph node status and age, progesterone and oestrogen receptor status predicted prognosis in middle aged (46-60 years) patients with lymph node positive breast cancer. Their prognostic effect in this subgroup, however, was restricted to the first five years after surgery. Progesterone receptor status was the strongest predictor of outcome. The prognostic power of oestrogen and progesterone receptor status varies depending on age, lymph node status and length of follow up after surgery.

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Citations

Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Yun NiuYing Wang
Jul 10, 2010·Breast Cancer Research and Treatment·Mohammed A AleskandaranyAndrew R Green
Jul 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S-D CostaM Kaufmann
Jun 29, 2004·Journal of Clinical Pathology·P J van DiestJ P A Baak
Apr 14, 2005·Annals of Surgical Oncology·Alessandro NeriEnrico Pinto
Dec 6, 2008·Folia Histochemica Et Cytobiologica·Anil K AgrawalEwa Nienartowicz
Jan 30, 2014·Journal of Geriatric Oncology·Heather S Laird-FickNikolay V Dimitrov
Oct 20, 2009·The Breast : Official Journal of the European Society of Mastology·R Stuart-HarrisH A Chaudri Ross
Sep 23, 2016·British Journal of Cancer·Elgene LimWayne D Tilley
Jan 11, 2017·Medicine·Hyun-June PaikSeok Jin Nam
Oct 16, 2004·Cadernos de saúde pública·Gulnar Azevedo e Silva MendonçaWagner Manoel Caula
Feb 6, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ivana Bozovic-SpasojevicChristos Sotiriou

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