Prognostic role of PET scanning before and after reduced-intensity allogeneic stem cell transplantation for lymphoma

Blood
Jonathan R LambertStephen Mackinnon

Abstract

Allogeneic stem cell transplantation (SCT) is an established therapy for patients with relapsed lymphoma, but the role of positron emission tomography (PET) scanning preallogeneic and postallogeneic SCT is uncertain. We investigated whether pretransplantation PET status predicted outcome after allogeneic SCT and whether PET surveillance after transplantation provided additional information compared with computed tomography (CT) scanning. Eighty consecutive patients with lymphoma who received a reduced-intensity allogeneic SCT were entered onto a prospective trial. PET and CT scans were performed before transplantation and up to 36 months after transplantation. Forty-two patients were PET-positive before transplantation. Pretransplantation PET status had no significant impact on either relapse rate or overall survival. Thirty-four relapses were observed, of which 17 were PET-positive with a normal CT scan at relapse. Donor lymphocyte infusion (DLI) was administered in 26 episodes of relapse and was guided by PET alone in 14 patients. These findings suggest that, in contrast to autologous SCT, pretransplantation PET status is not predictive of relapse and survival after allogeneic SCT for lymphoma. Posttransplantation surveillanc...Continue Reading

References

Jul 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A R YuenS J Horning
Jan 2, 1997·Bone Marrow Transplantation·M de LimaR E Champlin
Mar 14, 2003·European Journal of Nuclear Medicine and Molecular Imaging·D VisvikisP J Ell
Mar 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Douglas W Arthur, Frank A Vicini
Jan 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malik E JuweidUNKNOWN Imaging Subcommittee of International Harmonization Project in Lymphoma
Dec 27, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Adrian J C BloorStephen Mackinnon

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Citations

Jun 25, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jieun Uhm, John Kuruvilla
Sep 29, 2011·Current Opinion in Oncology·Koen van Besien
Sep 26, 2012·The Cancer Journal·Issa F Khouri, Richard E Champlin
Jun 7, 2011·Blood Reviews·Koen van Besien
Sep 23, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Lucia FarinaPaolo Corradini
May 20, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Veronika BachanovaUNKNOWN Center for International Blood and Marrow Transplant Research Lymphoma Working Committee
Jul 31, 2013·British Journal of Haematology·Kirsty J Thomson, Karl S Peggs
Oct 18, 2013·British Journal of Haematology·Sally Fiona Barrington, Nabegh George Mikhaeel
Jan 14, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·John G GribbenDavid G Maloney
Feb 19, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Craig S SauterCraig H Moskowitz
Apr 13, 2015·International Journal of Radiation Oncology, Biology, Physics·Susan M HinikerRichard T Hoppe
Oct 4, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Panayotis KaloyannidisAchilles Anagnostopoulos
Apr 21, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yasmin ReyalKarl S Peggs
Feb 2, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karl S PeggsStephen Mackinnon
Jun 13, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James O Armitage
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D Cheson
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ronjon Chakraverty, Stephen Mackinnon
Jun 14, 2017·Nature Reviews. Clinical Oncology·Joel CunninghamBhupinder Sharma
Sep 25, 2018·The Cancer Journal·Martin Hutchings
Jan 10, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Peter DregerUNKNOWN European Society for Blood and Marrow Transplantation (EBMT) and the Center for International Blood and Marrow Transplant Re
Nov 28, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Louise BouardPatrice Chevallier

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