Prognostic Role of Pretreatment Plasma D-Dimer in Patients with Solid Tumors: a Systematic Review and Meta-Analysis

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Wenhan LiDongmin Chang

Abstract

Elevated pretreatment plasma D-dimer level has been reported as an unfavorable prognostic indicator in several malignancies. The aim of this meta-analysis was to evaluate the prognostic value of elevated D-dimer level in solid tumors. A comprehensive search of electronic databases up to June 10, 2017 was carried out by two independent reviewers. We included studies exploring the association between pretreatment plasma D-dimer level and patients' survival outcomes in solid tumors. Overall survival (OS) was regarded as primary outcome and progression-free survival (PFS), disease-free survival (DFS) as well as cancer-specific survival (CSS) were chosen as secondary outcomes. Hazard ratio and 95% confidence interval (CI) were extracted directly or indirectly from included studies. 49 studies with 13001 patients were included in our meta-analysis. Elevated D-dimer was markedly associated with poor OS (pooled HR = 1.90, 95% CI = 1.63 - 2.20, P < 0.001). The effect was observed in all different tumor sites, disease stages, cut-off values and ethnicities. Meanwhile, patients with a high plasma D-dimer had a shorter PFS (HR = 1.46, 95% CI = 1.22-1.76; P < 0.001), DFS (HR = 2.02, 95% CI = 1.56-2.62) and CSS (HR = 2.04, 95% CI= 1.58 - 2.6...Continue Reading

Citations

Feb 14, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Junxun LiJing Cheng
Nov 2, 2019·Radiation Research·Natalia LounevaAnn R Kennedy
Jan 27, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Bo LiJianru Xiao
Jul 30, 2019·Canadian Journal of Gastroenterology & Hepatology·Hui-Shan WangLin Miao
Jun 23, 2020·The International Journal of Biological Markers·Ling QinYanqiu Wang
Oct 23, 2019·Signal Transduction and Targeted Therapy·Mrinal K GhoshMalini Basu
Feb 11, 2021·Technology in Cancer Research & Treatment·Jialong LiGuowei Che
Oct 12, 2020·Signal Transduction and Targeted Therapy·Mrinal K GhoshMalini Basu
Mar 31, 2021·European Journal of Internal Medicine·Hugo Ten Cate
Oct 9, 2021·Seminars in Thrombosis and Hemostasis·Anne Winther-LarsenAnne-Mette Hvas

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