Prognostic role of telomere length in malignancies: A meta-analysis and meta-regression

Experimental and Molecular Pathology
Roman AdamArnoud J Templeton

Abstract

Telomere length (TL) has been associated with several health conditions including cancer. To quantify the effect of TL on outcomes in malignancies and explore the role of type of TL measurement we conducted a librarian-led systematic search of electronic databases identified publications exploring the prognostic role of TL on cancer outcomes. Overall survival (OS) was the primary outcome measure while other time-to-event endpoints were secondary outcomes. Data from studies reporting a hazard ratio (HR) with 95% confidence interval (CI) and/or p-value were pooled in a meta-analysis. HRs were weighted by generic inverse variance and computed by random effects modeling. All statistical tests were two-sided. Sixty-one studies comprising a total of 14,720 patients were included of which 41 (67%) reported OS outcomes. Overall, the pooled HR for OS was 0.88 (95%CI=0.69-1.11, p=0.28). Long (versus short) telomeres were associated with improved outcomes in chronic lymphatic leukemia (CLL) and urothelial cancer (HR=0.45, 95%CI=0.29-0.71 and HR=0.68, 95%CI=0.46-1.00, respectively), conversely worse OS was seen with hepatocellular carcinoma (HR=1.90, 95%CI=1.51-2.38). Pooled HRs (95% CI) for progression-free survival, relapse/disease-free ...Continue Reading

Citations

Nov 17, 2017·International Journal of Molecular Sciences·Theresa VaskoPatrick Ziegler
Jan 6, 2018·International Journal of Molecular Sciences·Donogh MaguirePaul G Shiels
Feb 9, 2018·International Journal of Molecular Sciences·Kez ClealDuncan Baird
Jul 4, 2018·Leukemia & Lymphoma·Andrea KaifiePatrick Ziegler
Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sonja EntringerPathik D Wadhwa
May 3, 2019·PloS One·Daniel NettleMelissa Bateson
Sep 16, 2020·International Journal of Molecular Sciences·Marc BienzHans Knecht
Feb 9, 2021·Frontiers in Genetics·Alexander Vaiserman, Dmytro Krasnienkov

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