Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis

Technology in Cancer Research & Treatment
Xinliang MingJiancheng Tu

Abstract

The prognostic value of tenascin-C in different types of cancers remains controversial. To clarify its prognostic value on overall survival rates, we have conducted a meta-analysis to quantitatively assess the prognostic roles of tenascin-C for patients with cancer. We systematically searched all published studies about the role of tenascin-C in cancers on PubMed, Web of Science, Cochrane Library, and Embase. The pooled hazard ratio with 95% confidence intervals was used to analyze the association between tenascin-C expression level and overall survival of patients with cancer. The pooled odds ratio with 95% confidence intervals was used to investigate the association between tenascin-C expression level and clinicopathologic features of patients with cancer. Trial sequential analysis was performed to obtain the required information size. In this meta-analysis, 18 studies including 2732 patients were incorporated. The pooled hazard ratio of 18 trials was 1.73 (95% confidence interval: 1.29-2.32, P < .001) for overall survival, suggesting that elevated tenascin-C expression strongly predicted poor prognosis among patients with various cancers. Simultaneously, elevated tenascin-C expression was also significantly associated with l...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Oct 10, 1997·Cell and Tissue Research·A Faissner
Jul 8, 2003·The Journal of Pathology·Ruth Chiquet-Ehrismann, Matthias Chiquet
Dec 18, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kalpaj ParekhT Mohanakumar
Aug 18, 2005·Journal of the National Cancer Institute·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Apr 25, 2006·Cancer Letters·Gertraud Orend, Ruth Chiquet-Ehrismann
Dec 18, 2007·Journal of Clinical Epidemiology·Jørn WetterslevChristian Gluud
Dec 8, 2009·Science·Richard O Hynes
Dec 25, 2013·Molecular Medicine Reports·Zhenfeng GuanLei Li
Apr 4, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·D TastekinS Vatansever
Mar 5, 2015·Cell Adhesion & Migration·Camille M Lowy, Thordur Oskarsson
Mar 21, 2015·Cell Adhesion & Migration·Toshimichi YoshidaKyoko Imanaka-Yoshida
Jan 6, 2016·PloS One·Zhao-Ting YangSeok-Hyung Kim
Jan 30, 2016·Systematic Reviews·David MoherPaul Shekelle
Mar 12, 2016·Oncotarget·Florian GebauerMichael Tachezy
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 28, 2017·Biochemical and Biophysical Research Communications·Wei-Dong NiYan-Hua Xuan
Jun 16, 2017·PloS One·Felipe AndreiuoloUNKNOWN SIOP Ependymoma Biology Working Group BIOMECA (BIOlogical Markers for Ependymomas in Children and Adolescents)
Jun 28, 2017·Proceedings of the National Academy of Sciences of the United States of America·Vasilena GochevaTyler Jacks

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Citations

Dec 20, 2019·Journal of Neuro-oncology·Lai-Rong SongJun-Ting Zhang
Oct 27, 2020·Frontiers in Immunology·Masahiro HasegawaAkihiro Sudo

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

STATA
Engauge Digitizer

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