Prognostic role of the neutrophil-to-lymphocyte ratio in patients with primary central nervous system lymphoma

Oncotarget
Jongheon JungHyeon-Seok Eom

Abstract

Neutrophil-to-lymphocyte ratio (NLR) is one of the parameters of a complete blood cell count (CBC) test and has been reported to be an easily accessible prognostic marker in aggressive cancer, including non-Hodgkin lymphoma (NHL). Primary central nervous system lymphoma (PCNSL) is an extranodal NHL with highly aggressive features. However, the importance of the NLR has never been assessed in PCNSL. This retrospective study enrolled 62 biopsy-proven patients whose baseline NLR was available, and reviewed their medical records to compare both high (≥2.0) and low NLR (<2.0) groups, in terms of clinical characteristics and outcomes. The low NLR group showed significantly better response rates to induction chemotherapy compared to the high NLR group (p=0.041). At a median follow-up of 41.5 months, the high NLR group revealed a significantly worse 3-year overall survival (OS) (42.5 vs. 71.2%; p=0.031) and a worse 3-year progression-free survival (PFS) (37.3 vs. 60.1%; p=0.028). Univariable Cox analysis results showed that a high NLR at diagnosis was a poor prognostic factor for both 3-year OS (HR 2.64, 95% CI 1.06-6.60; p=0.038) and 3-year PFS (HR 2.41, 95% CI 1.07-5.42; p=0.034). However, multivariable analyses adjusting for Interna...Continue Reading

References

Mar 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L E AbreyJ Yahalom
Sep 6, 2000·Journal of Internal Medicine·H KuperD Trichopoulos
Oct 25, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Matthias H F Klinger, Wolfgang Jelkmann
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrés J M FerreriFranco Cavalli
Apr 26, 2003·American Journal of Clinical Oncology·Michael G AlexandrakisDespina S Kyriakou
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tamara N ShenkierJoseph M Connors
Jun 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lauren E AbreyUNKNOWN International Primary CNS Lymphoma Collaborative Group
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eiichi SatoKunle Odunsi
Dec 1, 2006·Neurosurgical Focus·Cigall KadochJames L Rubenstein
Jul 3, 2007·Cancer Immunology, Immunotherapy : CII·Femke HillenArjan W Griffioen
Apr 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carole SoussainUNKNOWN Société Française de Greffe de Moëlle Osseuse-Thérapie Cellulaire
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Khalid I Al-ShibliLill-Tove Busund
Sep 16, 2010·American Journal of Hematology·Luis F PorrataSvetomir N Markovic
Jan 25, 2011·Nature Reviews. Cancer·Laurie J Gay, Brunhilde Felding-Habermann
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sahar M A MahmoudAndrew R Green
Apr 4, 2014·Cancer Metastasis Reviews·David G MenterKenneth V Honn
Sep 18, 2014·Current Rheumatology Reviews·Carl S HendersonAnkoor Shah
Sep 29, 2015·American Journal of Hematology·Roopesh KansaraDiego Villa
Dec 9, 2015·Journal of Clinical Pathology·Katharina T TroppanMartin Pichler
May 22, 2016·Blood·Benjamin KasendaTracy T Batchelor
Oct 30, 2016·Journal of Clinical Laboratory Analysis·Supakanya WongrakpanichGabor Varadi

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Methods Mentioned

BETA
biopsy
surgical resection

Software Mentioned

R
SAS

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