Prognostic role of the sialyltransferase ST6GAL1 in ovarian cancer

Glycobiology
Beatrice WichertL Oliveira-Ferrer

Abstract

Aberrant sialylation of glycoproteins has been detected in many tumors, and upregulation of the beta-galactosamide alpha-2,6-sialyltransferase 1 (ST6GAL1) has been implicated with tumor aggressiveness and chemoresistance in experimental models. In our present study, we aimed to study the prognostic or predictive role of ST6GAL1 in ovarian carcinoma, using two independent ovarian cancer cohorts. ST6GAL1 mRNA levels were retrieved from a publicly available database (n = 517), and ST6GAL1 protein levels were analyzed by western blot analysis in a cohort of 204 ovarian tumor samples. The results were correlated with clinical and histological tumor parameters and follow-up information. High ST6GAL1 mRNA levels significantly correlated with lymphovascular invasion and shorter survival, whereas high ST6GAL1 protein expression was associated with advanced stage, distant metastasis and shorter recurrence-free intervals. In both cohorts the prognostic role was most pronounced in tumors without macroscopically visible residual tumor after surgery. In these cases, ST6GAL1 expression levels might help to identify cases with a higher risk of chemoresistance and metastatic relapse that might require an adapted therapeutic regime.

References

Apr 30, 2002·Experimental Cell Research·Shaoqiang LinPeter M Schlag
Aug 23, 2005·Gynecologic Oncology·Peng-Hui WangChiou-Chung Yuan
Aug 26, 2006·Breast Cancer Research and Treatment·Lisa M McShaneUNKNOWN Statistics Subcommittee of NCI-EORTC Working Group on Cancer Diagnostics
Mar 27, 2010·International Journal of Radiation Oncology, Biology, Physics·Minyoung LeeYun-Sil Lee
Dec 22, 2010·The Journal of Biological Chemistry·Ya Zhuo, Susan L Bellis
May 10, 2011·The Journal of Biological Chemistry·Amanda F Swindall, Susan L Bellis
Jul 2, 2011·Nature·UNKNOWN Cancer Genome Atlas Research Network
Sep 21, 2011·The Journal of Biological Chemistry·Zhongyu LiuSusan L Bellis
Dec 18, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Uros KuzmanovEleftherios P Diamandis
Apr 13, 2013·Journal of Ovarian Research·Matthew J SchultzSusan L Bellis
Aug 15, 2013·Journal of Cancer Research and Clinical Oncology·Kerstin EckhoffKarin Milde-Langosch
Dec 11, 2013·British Journal of Cancer·L Oliveira-FerrerK Milde-Langosch
Jan 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Hai-Ou LiuJie-Jie Xu
Mar 21, 2017·Seminars in Cancer Biology·Leticia Oliveira-FerrerKarin Milde-Langosch

❮ Previous
Next ❯

Citations

Oct 16, 2019·Journal of Ovarian Research·Kaitlyn A DorsettSusan L Bellis
Aug 20, 2019·Oncology Letters·Rebecca GarnhamJennifer Munkley
Sep 17, 2019·Expert Opinion on Therapeutic Targets·Anne Bärenwaldt, Heinz Läubli
Oct 28, 2019·Cancers·Linah F Al-AlemBo R Rueda
Nov 6, 2020·The Journal of Biological Chemistry·Colleen M BritainSusan L Bellis
Dec 16, 2020·Glycobiology·Kaitlyn A DorsettSusan L Bellis
Nov 5, 2020·British Journal of Cancer·Christopher Dobie, Danielle Skropeta
Jan 12, 2021·The Journal of Biological Chemistry·Colleen M BritainSusan L Bellis
Nov 7, 2021·International Journal of Cancer. Journal International Du Cancer·Anna Y BerghuisJohanna M A Pijnenborg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.