Prognostic role of tissue and circulating microRNA-200c in malignant tumors: a systematic review and meta-analysis

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Yingjie ShaoJingting Jiang

Abstract

Recently, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may serve as prognostic biomarkers. We performed a systematic review and meta-analysis to evaluate the prognostic role of miR-200c expression in different cancers. Studies were recruited by searching PubMed, Embase and the Cochrane Library (last search update was May 2014) and assessed by further quality evaluation. A total of 25 studies dealing with various carcinomas were identified for systematic review. Among them, 18 studies were ultimately included in the meta-analysis. Our results indicated that the expression of tissue miR-200c was not associated with OS and PFS in various carcinomas; however, downregulation of tissue miR-200c did predict poor OS of patients with stage I disease (HR=0.41, 95% CI 0.25-0.68, P=0.001). Furthermore, overexpression of blood miR-200c was significantly related to poor OS and PFS (HR=3.07 95% CI 1.58-5.96 P=0.001, HR=2.26 95% CI 1.66-3.08 P<0.001, respectively), especially in patients with advanced disease. This systematic review and meta-analysis clarified that low expression of miR-200c in primary tissue was significantly associated with poor survival in cancer patients at early stage, w...Continue Reading

Citations

Dec 1, 2015·Archives of Pathology & Laboratory Medicine·Donald E Henson, Philip M Grimley
Jun 24, 2015·Cancer Letters·Luis A AparicioAngélica Figueroa
Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Wei ZhangLiu Yang
Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Junjie XiaoSaumya Das
Apr 10, 2018·Journal of Cellular Biochemistry·Elaheh S Ghodousi, Soheila Rahgozar
Jan 23, 2018·Acta Obstetricia Et Gynecologica Scandinavica·Milosz WilczynskiAndrzej Malinowski
Aug 14, 2019·Journal of Cellular Biochemistry·Sheng YinMin Wang
Aug 21, 2018·Cancer Cell International·Ming ZhuangLiang Chen

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