Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis

Medicine
Jung Soo LeeYoon Ho Ko

Abstract

The potential prognostic value of tumor-infiltrating lymphocytes (TILs) in gastric cancer remains controversial. This meta-analysis examines the association between TILs and survival outcomes in gastric cancer. Twenty-two eligible studies were identified using the PubMed and Google Scholar databases. The combined sample size of the 22 studies was 2941, and the median sample size of the individual studies was 122 patients (52-220). The main clinical outcomes examined were overall cancer survival (OCS) and overall cancer relapse-free survival (OCRFS). Tumor tissue CD3(+) TILs, indicative of pan-T-cell expression, had a positive effect on survival with a hazard ratio (HR) of 0.64 (95% confidence interval [CI] 0.52-0.78) for OCS, as did the non-FOXP3(+) T-cell subgroup with an HR of 0.66 (95% CI 0.57-0.75), particularly in CD8(+) lymphocytes (HR = 0.63, 95% CI 0.48-0.83). On the contrary, high FOXP3(+) T-cell expression was correlated with reduced OCS, with an HR of 1.75 (95% CI 1.26-2.42). Analysis of the seven studies evaluating OCRFS revealed improved OCRFS with infiltration of non-FOXP3(+) TILs with an HR of 0.59 (95% CI 0.42-0.81) but not FOXP3(+) T lymphocytes with an HR of 1.82 (95% CI 1.30-2.53). The results from this meta-...Continue Reading

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Citations

Sep 9, 2019·Cancer Science·Shamaine Wei Ting Ho, Patrick Tan
Oct 19, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Abhineet UppalAnton J Bilchik
Jul 18, 2019·Annals of Surgical Oncology·Yoshiyuki SasakiMasayuki Sho
Dec 4, 2019·International Journal of Oncology·Mohamed E M SaeedThomas Efferth
Sep 22, 2020·Virchows Archiv : an International Journal of Pathology·Naziha MansuriOlli Carpén
Mar 7, 2021·International Journal of Molecular Sciences·Dita UlaseChristoph Röcken
Apr 18, 2021·Cellular Oncology (Dordrecht)·Niclas C BlessinStefan Steurer

Related Concepts

Neoplasm Recurrence, Local
Hereditary Diffuse Gastric Cancer
Cox Proportional Hazards Models
Lymphocytes, Tumor-Infiltrating
Suppressor T-Lymphocytes, CD8-Positive
Progression-Free Survival
Biological Markers
Malignant Neoplasms
Cell Survival
Lymphocyte

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