Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma

PloS One
Hongwei ZhangCongjian Xu

Abstract

Chronic inflammation is a well-known epidemiologic factor of ovarian clear cell carcinomas (OCCC), but has an uncertain role in prognosis. We developed a systemic inflammation score (SIS) based on preoperative serum albumin and neutrophil-to-lymphocyte ratio (NLR) for predicting progression-free survival (PFS) and overall survival (OS) in OCCC patients. A retrospective review was performed in 155 patients with OCCC undergoing primary debulking and chemotherapy at a single institute between 1995 and 2010. Cox regression models were fitted to analyze the effect of prognostic factors on PFS and OS. Harrell's concordance index was calculated to assess predictive accuracy. The SIS consisting of serum albumin and NLR was retained as an independent indicator adjusting for traditional clinicopathological features. A high SIS was significantly associated with aggressive tumor behavior, platinum resistance, and served as an independent predictor of reduced PFS (P = 0.006) and OS (P = 0.019). The SIS had a good discrimination ability for the predictive PFS (c-index = 0.712) and OS (c-index = 0.722). We have developed a system inflammation score for predicting prognosis of OCCC patients, which may help stratify patients for postsurgical ma...Continue Reading

References

Jun 21, 2008·Scandinavian Journal of Immunology·M KlinkZ Sulowska
Feb 8, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·R B GonçalvesF H Nociti
Jul 2, 2011·Nature·UNKNOWN Cancer Genome Atlas Research Network
Jul 22, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Viren AsherAnish Bali
Jan 31, 2012·Biology of Sex Differences·Ilaria CampesiFlavia Franconi
Mar 1, 2012·The Lancet Oncology·Celeste Leigh PearceUNKNOWN Ovarian Cancer Association Consortium
Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
May 4, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julie S NielsenBrad H Nelson
Jul 4, 2012·Oncoimmunology·Shuang WeiWeiping Zou
Oct 25, 2012·Journal of Gynecologic Oncology·Supachai RaungkaewmaneeThaovalai Thavaramara
Apr 23, 2013·Critical Reviews in Oncology/hematology·Graeme J K GuthrieStephen J Clarke
Oct 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J A LedermannUNKNOWN ESMO Guidelines Working Group
Jan 28, 2014·Gynecologic Oncology·Kristina A WilliamsDaniel W Cramer
Apr 29, 2014·Lancet·Gordon C JaysonJonathan A Ledermann
May 31, 2014·Journal of the National Cancer Institute·Arnoud J TempletonEitan Amir
Oct 5, 2014·The Lancet Oncology·Connie I DiakosStephen J Clarke
Oct 9, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Swati SuryawanshiAnda M Vlad
Mar 13, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hee Seung KimYong Sang Song
Jun 13, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wei-Wei ZhangWei-Jiang Liang
Oct 18, 2015·Cancer Research·Zvi Granot, Zvi G Fridlender
Dec 25, 2015·Trends in Immunology·Davalyn R Powell, Anna Huttenlocher
Mar 24, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yuan-Qiu WangFeng Lin
May 14, 2016·Gynecologic Oncology·Taylor B TurnerRebecca C Arend

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Citations

May 28, 2019·Minerva medica·Giacomo CorradoGabriella Ferrandina
Oct 3, 2019·Journal of Gynecologic Oncology·Kosuke YoshidaFumitaka Kikkawa
Feb 23, 2021·Frontiers in Immunology·Gulcin TezcanSvetlana F Khaiboullina
Mar 4, 2021·Annals of Surgical Oncology·Sasinthiran ThiagarajanChin-Ann Johnny Ong

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