Prognostic significance of a positive surgical margin in pathologically organ-confined prostate cancer

BJU International
Sascha A AhyaiFelix K-H Chun

Abstract

To identify risk factors of a positive surgical margin (PSM) and the significance of a PSM after radical prostatectomy (RP) on biochemical recurrence (BCR) in exclusively pathologically confirmed organ-confined (OC) prostate cancer, as despite an excellent prognosis after RP, some patients with pathologically confirmed OC disease have BCR, and the prognostic significance of a PSM in these men remains unclear. We assessed 932 men with pathologically OC disease who were treated with RP by nine different surgeons between 1992 and 2004. The prognostic significance of clinical and pathological variables, including tumour volume (TV) and percentage of high-grade TV (%HGTV) were assessed. Logistic and Cox regression models were fitted to identify risk factors of a PSM and BCR. BCR was defined as a prostate-specific antigen (PSA) level of 0.1 ng/mL and increasing after an undetectable PSA level. The total PSM rate was 12.9% (120 men); the mean TV (P < 0.001), but not %HGTV (P= 0.2) was significantly higher in patients with PSM. TV, nerve-sparing RP technique and surgical volume were independent risk factors for a PSM (P= 0.03). After a median follow-up of 35 months the overall BCR rate was 8.8% (82 men). Patients with a PSM had signifi...Continue Reading

References

May 14, 1982·JAMA : the Journal of the American Medical Association·F E HarrellR A Rosati
Oct 1, 1994·The Journal of Urology·R P HenkeH Huland
Apr 27, 1999·JAMA : the Journal of the American Medical Association·T A StameyI M Johnstone
Mar 12, 2003·The Journal of Urology·Anthony V D'AmicoMing-Hui Chen
May 29, 2003·The Journal of Urology·Stephen J FreedlandUNKNOWN SEARCH Database Study Group
Jul 13, 2004·The Journal of Urology·Eiji KikuchiMakoto Ohori
Dec 8, 2005·European Urology·Markus GraefenHartwig Huland
Feb 14, 2006·The Journal of Urology·Thomas SteuberPierre I Karakiewicz
Jan 16, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Felix K-H ChunPierre I Karakiewicz
Apr 22, 2008·The Journal of Urology·Ofer YossepowitchPaul Russo

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Citations

Nov 24, 2011·Prostate Cancer·Kenneth A Iczkowski, M Scott Lucia
Jun 16, 2011·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Nathan LawrentschukNeil E Fleshner
Feb 18, 2018·Virchows Archiv : an International Journal of Pathology·Metka VolavšekAntonio Lopez-Beltran
Mar 16, 2013·BJU International·Philip A Fontenot, Ahmed M Mansour

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