Prognostic significance of ADAM17 expression in patients with gastric cancer who underwent curative gastrectomy

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
D AydinM Aliustaoglu

Abstract

A disintegrin and metalloproteinase (ADAM) 17 has been indicated to be an indispensable regulator of cellular events from proliferation to migration. Although prognostic importance of ADAM17 expression has been investigated in several tumours, its clinical utility as a useful prognostic molecular marker remains unclear in gastric cancer. In the current study, we evaluated the expression of ADAM17 and its prognostic significance in gastric cancer patients after curative gastrectomy. The prognostic significance of ADAM17 expression was analysed immunohistochemically in 156 patients with gastric cancer who had undergone curative gastrectomy, and the relationship between its expression and clinicopathological factors was also evaluated. High ADAM17 expression was detected in 79 patients (51 %), whereas low expression was found in 77 cases (49 %). There was significant correlation between gender, histology, lymph node metastasis, vascular invasion, the presence of recurrence and high ADAM17 expression. Recurrence in patients with high ADAM17 expression was significantly higher than that for patients with low ADAM17 expression (p = 0.032). The median disease-free survival (DFS) time for patients with tumours with high ADAM17 expressi...Continue Reading

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Citations

Apr 26, 2016·BioMed Research International·Katarzyna WalkiewiczMałgorzata Muc-Wierzgoń
Sep 24, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hongyu ShenJinhai Tang
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Laurine VersetPieter Demetter
Mar 15, 2020·Journal of Neuro-oncology·Yuduo GuoHongwei Zhang

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