Prognostic significance of altered miRNA expression in whole blood of OSCC patients

Oncology Reports
Jutta RiesEmeka Nkenke

Abstract

Currently, there is a lack of blood markers for the detection of recurrent oral squamous cell carcinoma (OSCC). The present study aimed to investigate whether the aberrant expression of single microRNAs (miRNAs) in whole blood of patients could serve as a biomarker for persistent or recurrent OSCC. Whole blood of 2 groups of formerly treated OSCC patients was investigated by RT-qPCR for their circulating miRNA profiles. The R-OC group included patients with recurrence of OSCC (n=21) and the NR-OC group included patients without recurrence (n=21). Fold-changes and significance of the differences in miRNA expression levels between the groups were determined. A cut-off point (COP) for the discrimination between the R-OC and NR-OC groups was calculated and the significance between over/under expression of the miRNAs and the recurrence of malignancy was determined. Significant differences in the miRNA expression in whole blood of the R-OC and NR-OC groups were found. The levels of miR-3651 and miR-494 were significantly increased and the level of miR-186 was significantly decreased in whole blood of the R-OC patients (pmiR-3651=0.001, pmiR-494=0.003 and pmiR-186=0.001). By the determination of the COP, increased or decreased express...Continue Reading

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Citations

Oct 4, 2019·Oncology Letters·Chuan Fang, Yadong Li
Jul 21, 2020·Head & Neck·Fiona T DeutschNham T Tran
Jun 18, 2020·Frontiers in Oncology·Ruma Dey GhoshSusanta Roychoudhury
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Nov 19, 2020·Heliyon·Soudeh Ghafouri-FardZeinab Shirvani Farsani
Nov 19, 2020·Cancer Management and Research·Hong-Yu Zhang, Jian-Hui Ma

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