PMID: 15368686Sep 17, 2004Paper

Prognostic significance of angiogenesis in superficial bladder cancer

International Urology and Nephrology
N E StavropoulosN Agnantis

Abstract

To assess the prognostic significance of angiogenesis parameters such as microvessel density (MVD) and vascular endothelial growth factor (VEGF) in superficial bladder cancer. We studied 127 superficial bladder cancer samples immunohistochemically for the above factors. We compared them with standard clinicopathological features (grade, stage, concurrent in situ, multifocality, primary or recurrent status) as well as with p53 expression, recurrence and progression to muscle infiltrating disease. During a 36 months median follow up of 109 patients with superficial primary tumors (min. 3, max. 69 months), 80 of them recurred (73.4%), while 8 patients (7.3%) progressed to muscle invading disease. A significant correlation was noted between MVD and VEGF in all 127 samples (p = 0.019). No association was noted between MVD or VEGF with the other clinicopathological features, recurrence or progression. Although progression free survival rates of categorized microvessel density (up to and higher than median value) differed significantly only in grade 3 patients, no independent prognostic significance could be attributed to MVD. No correlation was observed between MVD or VEGF with p53 protein. Based on our data we suggest that VEGF is n...Continue Reading

Citations

Feb 25, 2010·European Radiology·Han Feng YangYang Li
Apr 10, 2008·Pathology Oncology Research : POR·Anna ThielemannAleksandra Baszczuk
Mar 24, 2009·AJR. American Journal of Roentgenology·Nermin TuncbilekMustafa Kemal Demir
Jul 19, 2014·Critical Reviews in Clinical Laboratory Sciences·Francesca SanguedolceLuigi Cormio
Oct 25, 2011·Annals of Diagnostic Pathology·Aysegul SariKaan Bal
Oct 15, 2009·World Journal of Gastrointestinal Oncology·Farha A El-ChennawiZakaria F Lotfy

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