Prognostic significance of anti-aminoacyl-tRNA synthetase antibodies in polymyositis/dermatomyositis-associated interstitial lung disease: a retrospective case control study

PloS One
Hironao HozumiT Suda

Abstract

In polymyositis/dermatomyositis (PM/DM), anti-aminoacyl-tRNA synthetase (ARS) antibodies are closely associated with interstitial lung disease (ILD), a frequent pulmonary complication. However, the clinical significance of anti-ARS antibodies is not well established. We aimed to evaluate the clinical significance of anti-ARS antibodies in PM/DM-ILD patients. Forty-eight consecutive PM/DM-ILD patients were studied retrospectively. Anti-ARS antibodies were screened by ELISA and confirmed by RNA immunoprecipitation test. Medical records, high-resolution computed tomography images, and surgical lung biopsy specimens were compared between ARS-positive (ARS group) and ARS-negative patients (non-ARS group). Anti-ARS antibodies were detected in 23 of 48 patients (48%). Radiologically, nonspecific interstitial pneumonia (NSIP) pattern was observed more frequently in the ARS group than in the non-ARS group (73.9% vs. 40%, P = 0.02). Pathologically, NSIP was the most frequent in both groups. Ten-year survival rate was also significantly higher in the ARS group than in the non-ARS group (91.6% vs. 58.7%, P = 0.02). Univariate Cox hazards analysis revealed that the presence of anti-ARS antibodies was associated with better prognosis (HR = 0...Continue Reading

References

Feb 20, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Feb 13, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·W W DouglasJ H Ryu
Jan 11, 2003·Arthritis and Rheumatism·I MarieH Courtois
Sep 4, 2003·The European Respiratory Journal·V CottinUNKNOWN Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires
Jul 14, 2006·The European Respiratory Journal·T SudaK Chida
Jan 16, 2008·Radiology·David M HansellJacques Remy
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Apr 26, 2011·Respiratory Medicine·Kizuku WatanabeMichiaki Mishima
Jun 3, 2011·Respiratory Medicine·Kiminobu TanizawaMichiaki Mishima
Dec 4, 2012·Arthritis Care & Research·I MarieF Jouen
Feb 21, 2013·Annals of the Rheumatic Diseases·Rohit AggarwalChester V Oddis
Mar 15, 2013·Respiratory Medicine·Kiminobu TanizawaMichiaki Mishima
Jun 26, 2013·Current Rheumatology Reports·Baptiste Hervier, Olivier Benveniste
Sep 17, 2013·American Journal of Respiratory and Critical Care Medicine·William D TravisUNKNOWN ATS/ERS Committee on Idiopathic Interstitial Pneumonias
Jun 4, 2014·Journal of Clinical Pathology·Frank SchneiderRohit Aggarwal
Jun 7, 2014·PloS One·Tomoyuki FujisawaTakafumi Suda

❮ Previous
Next ❯

Citations

Oct 18, 2015·The Medical Clinics of North America·Andrea Kalus
Nov 26, 2015·Journal of Internal Medicine·Z Betteridge, N McHugh
Dec 4, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Ryuichi TogawaMitsuru Munakata
Apr 11, 2018·Current Rheumatology Reports·Paige W Wolstencroft, David F Fiorentino
Aug 19, 2015·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Hidenaga KawasumiHisashi Yamanaka
Mar 13, 2018·Internal Medicine·Go SaitoHidenori Nakamura
May 4, 2017·The Journal of Rheumatology·Jingli ShiGuochun Wang
Jul 18, 2017·The Journal of Rheumatology·Hironao HozumiTakafumi Suda
Mar 19, 2020·The European Respiratory Journal·Pierre-Marie BoutanquoiPhilippe Bonniaud
Jul 14, 2020·Current Opinion in Pulmonary Medicine·Toyoshi Yanagihara, Yoshikazu Inoue
Feb 16, 2019·Journal of Immunology Research·Charles CassiusReyhan Amode
Apr 3, 2019·Immunological Medicine·Ran Nakashima
Nov 13, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tomoyuki FujisawaTakafumi Suda
Feb 26, 2021·Clinical Rheumatology·Mithu MaheswaranathanLisa Criscione-Schreiber
May 1, 2021·Medicina·Tomoyuki Fujisawa
May 11, 2021·Frontiers in Immunology·Andrea Aguilar-VazquezMonica Vazquez-Del Mercado

❮ Previous
Next ❯

Methods Mentioned

BETA
immunoprecipitation
enzyme-linked immunosorbent assay
ELISA
biopsy
bronchoalveolar lavage
RNA-IP
bronchoalveolar
lavage

Software Mentioned

JMP

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.