Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Socorro María Rodríguez-PinillaJosé Palacios

Abstract

Basal-like phenotype tumors are frequently found among BRCA1 germ-line mutated breast carcinomas. They are biologically aggressive and have a tendency towards visceral metastasis when untreated. Nevertheless, it has been suggested that they respond to chemotherapy better than other types of tumors. Fascin expression has been associated with lung metastasis in breast cancer. The aim of this study was to determine whether basal-like phenotype and fascin were related in both sporadic and familial tumors and with prognosis in node-negative sporadic breast cancers. 230 nonfamilial and 28 hereditary node-negative invasive breast carcinomas were immunohistochemically analyzed using tissue microarrays. Tumors that were estrogen receptor/HER2 negative and cytokeratin 5/6 and/or epidermal growth factor receptor positive were considered to have a basal-like phenotype. A basal-like phenotype was found in 11.9% of sporadic cancers. Among patients not receiving adjuvant chemotherapy, a basal-like phenotype was associated with poor prognosis (P = 0.001, log-rank test) whereas no such association was found in patients receiving it. Tumors with a basal-like phenotype showed local recurrence (17.4%) or visceral metastasis (13%) but not bone meta...Continue Reading

References

Jul 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R B NagleE D Jarasch
Jul 6, 1988·Journal of the National Cancer Institute·S H DairkeeA J Hackett
Aug 30, 2000·Nature·C M PerouD Botstein
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Jul 9, 2002·Journal of Cutaneous Pathology·Werner KempfMarshall E Kadin
Aug 6, 2002·Journal of Medical Genetics·P O ChappuisW D Foulkes
Feb 13, 2003·American Journal of Clinical Pathology·Guang FanRita M Braziel
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Oct 2, 2003·Journal of the National Cancer Institute·William D FoulkesLars A Akslen
Oct 22, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giuseppe PelosiGiuseppe Viale
Feb 6, 2004·Brain Tumor Pathology·Aurelia PeraudJames T Rutka
Apr 6, 2004·The International Journal of Biochemistry & Cell Biology·Andrea Buda, Massimo Pignatelli
Apr 10, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rachel Kesse-Adu, Sami Shousha
May 6, 2004·Journal of the National Cancer Institute·José PalaciosJavier Benítez
May 12, 2004·Cancer Biology & Therapy·N Tjarda Van HeekMichael Goggins
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenCharles M Perou
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chris JonesSunil R Lakhani
Oct 7, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Karen L GroggAntonio G Nascimento
Nov 24, 2004·Oncology·Yosuke HashimotoMasayuki Imamura
Dec 18, 2004·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Takeshi SakumaYoshiko Yamaguchi
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yosuke HashimotoYutaka Shimada
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jarle B ArnesWilliam D Foulkes
Jun 4, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Emiliano HonradoJosé Palacios
Jun 24, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L AlbigesS Delaloge
Jul 2, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mervi LaaksoJorma Isola
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sunil R LakhaniUNKNOWN Breast Cancer Linkage Consortium
Jul 29, 2005·Nature·Andy J MinnJoan Massagué
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roman RouzierLajos Pusztai
Sep 17, 2005·The Journal of Pathology·Jocelyne JacquemierUNKNOWN Breast Cancer Linkage Consortium

❮ Previous
Next ❯

Citations

Nov 2, 2011·International Journal of Clinical Oncology·Xiao Feng DuanQiang Li
Apr 14, 2007·Breast Cancer Research and Treatment·Karin LeunenIgnace Vergote
Jun 11, 2008·Breast Cancer Research and Treatment·Rebecca DentSteven A Narod
Jun 20, 2008·Breast Cancer Research and Treatment·Wen-Jin YinZhi-Ming Shao
Mar 11, 2008·Breast Cancer Research and Treatment·Emad A RakhaIan O Ellis
Mar 17, 2010·Breast Cancer Research and Treatment·Edith A PerezAlvaro Moreno-Aspitia
Jun 25, 2010·Breast Cancer Research and Treatment·Jung Ah LeeUNKNOWN Korean Breast Cancer Society
Apr 26, 2011·Breast Cancer Research and Treatment·Sarah J NyanteRobert C Millikan
Jan 27, 2009·Cancer Metastasis Reviews·Mahmut Yilmaz, Gerhard Christofori
Jan 25, 2012·Clinical & Experimental Metastasis·Vanisri RavirajLilian Soon
Feb 2, 2013·Clinical & Experimental Metastasis·S BayraktarB K Arun
Jun 1, 2006·Familial Cancer·William D Foulkes
May 13, 2010·Journal of Mammary Gland Biology and Neoplasia·Nathan J GoddePatrick O Humbert
Feb 9, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jing ChenWei Xiong
Jul 30, 2010·Medical Oncology·Erhan AraratKadri Altundag
Dec 11, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Marta Hergueta-RedondoGema Moreno-Bueno
Nov 16, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sunil BadveJorge S Reis-Filho
Mar 8, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rabab A A MohammedStewart G Martin
May 25, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer R WonTorsten O Nielsen
Mar 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Socorro M Rodriguez-PinillaJose Palacios
Mar 31, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hiroshi YamaguchiMasazumi Tsuneyoshi
Sep 22, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Enrique LermaAgustí Barnadas
Sep 22, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Emiliano HonradoJavier Benítez
Apr 16, 2010·Nature·Lin ChenXin-Yun Huang
Jan 24, 2008·Nature Clinical Practice. Oncology·Oluwole Fadare, Fattaneh A Tavassoli
Sep 30, 2010·Nature Reviews. Clinical Oncology·Lisa CareyLuca Gianni
Sep 26, 2006·Oncogene·N C Turner, J S Reis-Filho
Jan 7, 2011·The New England Journal of Medicine·Joyce O'ShaughnessyCharles Bradley
Nov 12, 2010·The New England Journal of Medicine·William D FoulkesJorge S Reis-Filho
Nov 28, 2012·The Journal of Biological Chemistry·Shengyu YangXin-Yun Huang
Aug 7, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN 10th St. Gallen conference
Jan 20, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Fasano, F Muggia
Sep 18, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D WuL Liu
Nov 11, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O GluzN Harbeck
Oct 30, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S De SummaS Tommasi
Sep 19, 2012·Nucleic Acids Research·Sameer PhalkeErnesto Guccione
Apr 7, 2007·The American Journal of Surgical Pathology·Socorro María Rodríguez-PinillaJosé Palacios
Jan 17, 2008·Current Opinion in Obstetrics & Gynecology·Soonmo Peter KangLyndsay N Harris
Jul 22, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Enrique LermaJaime Prat
Apr 23, 2010·The American Journal of Surgical Pathology·Charles ChanStephen Clarke
May 25, 2010·The American Journal of Surgical Pathology·Aye Aye ThikePuay Hoon Tan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Therese SørlieA L Børresen-Dale
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Torsten O NielsenCharles M Perou
Proceedings of the National Academy of Sciences of the United States of America
Therese SorlieDavid Botstein
© 2021 Meta ULC. All rights reserved