Prognostic significance of c-Met, β-catenin and FAK in patients with hepatocellular carcinoma following surgery

Oncology Letters
Xue-Yi GongQian Wang

Abstract

The present study aimed to investigate the prognostic value of specific molecular markers in patients with hepatocellular carcinoma (HCC) who had received surgery. Immunohistochemical analysis was used to measure the expression of hepatocyte growth factor receptor (c-Met), β-catenin and focal adhesion kinase (FAK) in patients with HCC. c-Met expression was identified to be high in patients with larger tumors, higher α-fetoprotein (AFP) levels, higher Edmondson grades, portal vein invasion and higher tumor-node-metastasis (TNM) stages. FAK expression was high in patients with portal vein invasion, higher Edmondson grades and higher TNM stages. β-catenin expression was high in patients with larger tumors, hepatitis B virus (HBV) infection, portal vein invasion, higher Edmondson grades and higher TNM stages. Following multivariate analysis, FAK (P=0.002) and β-catenin (P=0.006) expression levels were demonstrated to be significantly associated with Edmondson grade. Additionally, the tumor size (P=0.009) and HBV infection status (P=0.002) were revealed to be associated with β-catenin expression. Kaplan-Meier survival curve analysis demonstrated that patients with HCC with higher FAK expression, higher β-catenin expression, portal v...Continue Reading

References

Aug 1, 1992·Seminars in Liver Disease·C E Rogler, F V Chisari
Feb 1, 1973·American Journal of Surgery·C T CalabreseH Volk
Nov 1, 1983·Journal of the American Geriatrics Society·W B ErshlerC J Greene
Jan 15, 1993·Biochemical and Biophysical Research Communications·E André, M Becker-André
Jun 4, 1999·Progress in Biophysics and Molecular Biology·D D SchlaepferD J Sieg
Oct 24, 2000·Oncogene·J H LeeG F Vande Woude
Mar 18, 2003·Journal of Cell Science·J Thomas Parsons
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shinji ItohYoshihiko Maehara
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Satyajit K MitraDavid D Schlaepfer
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nelson FaustoKimberly J Riehle
May 20, 2006·The Journal of Clinical Investigation·Pal Kaposi-NovakSnorri S Thorgeirsson
Aug 25, 2006·Nature Reviews. Cancer·Paraskevi A Farazi, Ronald A DePinho
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Sep 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josep M Llovet, Jordi Bruix
Dec 23, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Benjamin CieplySatdarshan P S Monga
Jan 27, 2009·Cancer Metastasis Reviews·Jihe Zhao, Jun-Lin Guan
May 13, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Liang LiuZhao-You Tang
Dec 2, 2010·Advanced Drug Delivery Reviews·Xiaofeng Zhao, Jun-Lin Guan
Feb 18, 2011·Cancer Research·Jimmy K StaufferRobert H Wiltrout
Aug 29, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Na ShangWei Qiu
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Aug 1, 2012·Korean Journal of Hepato-biliary-pancreatic Surgery·Ki Hoon Kim, Young-Kil Choi

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Citations

Mar 3, 2020·Frontiers in Cell and Developmental Biology·Haiyu WangZujiang Yu

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