Prognostic significance of cancer volume involving seminal vesicles in patients with pT3bpN0 prostate cancer

Urology
Shinya YamamotoIwao Fukui

Abstract

To investigate the prognostic effect of the prostate cancer (PCa) volume involving the seminal vesicles (CVSVs) in the radical prostatectomy specimen from patients with Stage pT3bpN0 PCa. We retrospectively reviewed the clinical records of 27 patients with Stage pT3bpN0 PCa who had undergone radical prostatectomy alone. We measured the CVSVs using a grid method on the glass slide under microscopic inspection and investigated the association of the CVSVs with clinicopathologic variables. Prostate-specific antigen (PSA) failure was confirmed in 11 of the 27 patients (41%) during a median follow-up of 34 months. The 3-year PSA failure-free survival rate was 48%. The median CVSVs was 1.14 cm(3). On univariate analysis, a CVSVs of >1.63 cm(3) was associated with positive surgical margins (P = .018), bilateral seminal vesicle involvement (P = .03), a long maximal tumor dimension (P = .031), and a greater preoperative PSA level (P = .0007). The 3-year PSA failure-free survival rate for those with a CVSVs of <or=1.63 cm(3) vs >1.63 cm(3) was 80% and 0%, respectively (P = .0009). On multivariate analysis, only the PSA level and CVSVs were identified as significant and independent predictors of PSA failure. Stratifying patients into 3 ri...Continue Reading

References

Dec 1, 1993·The American Journal of Surgical Pathology·M OhoriT M Wheeler
Aug 16, 2005·Lancet·Michel BollaUNKNOWN European Organization for Research and Treatment of Cancer
Nov 16, 2006·JAMA : the Journal of the American Medical Association·Ian M ThompsonE David Crawford
Aug 28, 2007·Japanese Journal of Clinical Oncology·Satoru KawakamiYuichi Ishikawa

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Citations

Sep 8, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daniel M BerneyUNKNOWN ISUP Prostate Cancer Group
Oct 16, 2012·Seminars in Diagnostic Pathology·Adeboye O Osunkoya, David J Grignon
Jun 10, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Shinya YamamotoIwao Fukui
Apr 8, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Makoto OhoriMasaaki Tachibana
May 20, 2015·Japanese Journal of Clinical Oncology·Takahiro InoueOsamu Ogawa
Jun 17, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Hyun Jung LeeSung-Woo Park
Jul 23, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Arinobu FukunagaAkiko Miyagi Maeshima
Aug 2, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Shinya Yamamoto

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