Prognostic significance of Cbx4 expression and its beneficial effect for transarterial chemoembolization in hepatocellular carcinoma

Cell Death & Disease
H-K JiaoG-Q Chen

Abstract

Our recent investigations showed that polycomb chromobox 4 (Cbx4) promotes angiogenesis and metastasis of hepatocellular carcinoma (HCC) through its sumoylating action on hypoxia-inducible factor-1α protein. Here, we attempt to identify the prognostic significances of Cbx4 by a retrospective analyses in 727 cases of HCC patients with and without postoperative transarterial chemoembolization (TACE) or transarterial embolization (TAE). Binary logistic regression tests indicated that Cbx4 is correlated with histological grading, tumor-node-metastasis stage, microvessel density, distant metastasis and hematogenous metastasis of HCC. By univariate and multivariate analyses, we show that Cbx4 is an independent prognostic factor of HCC, and both TAE and TACE treatments have no effects on the overall survival in HCC patients with low Cbx4 expression. More intriguingly, TACE prolongs, while TAE shortens, the overall survival of HCC patients with high Cbx4 expression, indicating that Cbx4 is a good biomarker on decision-making to perform postoperative TACE in HCC patients. Moreover, Cbx4 overexpression enhances while Cbx4 silencing antagonizes doxorubicin-induced cell death of HCC cell lines. In conclusion, Cbx4 is an independent prognos...Continue Reading

References

Dec 15, 1993·Cancer·K FriedrichsW Jonat
Apr 8, 2003·Cell·Michael H KageyDavid Wotton
Sep 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Suk Woo NamJung Young Lee
Oct 22, 2005·Cancer Letters·Roberta PangRonnie T P Poon
Aug 22, 2006·Biochimie·Pamela Völkel, Pierre-Olivier Angrand
Feb 13, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Christopher D MannDavid P Berry
Nov 23, 2007·Biochemical Society Transactions·D Wotton, J C Merrill
Apr 29, 2008·Current Opinion in Cell Biology·Yuri B Schwartz, Vincenzo Pirrotta
Apr 21, 2009·Expert Review of Anticancer Therapy·Richard S Finn, Andrew X Zhu
Sep 10, 2009·Nature Reviews. Molecular Cell Biology·Jeffrey A Simon, Robert E Kingston
Jun 22, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Riccardo Lencioni
Sep 21, 2010·Seminars in Cancer Biology·Polina IakovaNikolai A Timchenko
Oct 5, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jian-Hong Zhong, Le-Qun Li
Feb 26, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rita GolfieriLuigi Bolondi
Oct 20, 2011·Journal of Hepatology·Alejandro FornerJordi Bruix
Feb 23, 2012·Lancet·Alejandro FornerJordi Bruix
Apr 20, 2012·Mini Reviews in Medicinal Chemistry·Z Z DongD F Yao
Jul 25, 2012·The Journal of Biological Chemistry·Federico PelischAnabella Srebrow
Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R A Pazo-CidP Martín-Duque
Apr 12, 2013·The Oncologist·Keeran R Sampat, Bert O'Neil
Aug 15, 2013·Annals of Surgical Oncology·Boqing WangTiebang Kang
Oct 26, 2013·Liver Cancer·Agrin MoeiniAugusto Villanueva
May 7, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sung-Min AhnGu Kong
Jun 12, 2014·Science China. Life Sciences·Jie LiGuoQiang Chen
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Silvia Vilarinho, Diego F Calvisi
Jul 23, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alessandro CucchettiAntonio Daniele Pinna
Jul 30, 2014·Trends in Cell Biology·Jesús Gil, Ana O'Loghlen
Aug 6, 2014·Nature Reviews. Clinical Oncology·Alejandro FornerJean-Luc Raoul

❮ Previous
Next ❯

Citations

Dec 10, 2015·Biochemistry·Natalia Milosevich, Fraser Hof
Mar 16, 2016·Biochimica Et Biophysica Acta·Filomena de Nigris
Jun 18, 2016·Molecular & Cellular Oncology·Haifeng Jiao, Han You
May 6, 2019·International Journal of Molecular Sciences·Natalia García-SanchaJavier Cañueto
Aug 4, 2016·Alimentary Pharmacology & Therapeutics·B BockH Bantel

❮ Previous
Next ❯

Methods Mentioned

BETA
sumoylation
sumoylations

Software Mentioned

SPSS
GraphPad Prism
Statistical Package for the Social Sciences ( SPSS
GraphPad

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.