Prognostic significance of CD44v6, p63, Podoplanin, and MMP-9 in oral squamous cell carcinomas

Oral Diseases
Luís Silva MonteiroSaman Warnakulasuryia

Abstract

To analyse the expression of the CD44v6, p63, podoplanin and MMP-9, and their prognostic significance in patients with oral squamous cell carcinomas (OSCC). Immunohistochemistry technique was performed on 60 OSCC for detection of CD44v6, p63, podoplanin and MMP-9 proteins. Extent and intensity of staining were evaluated in tumour cells and were compared with patient's clinical-pathological characteristics and survival. CD44v6 expression was detected at the membrane of tumour cells of 94% cases. Nuclear expression of p63 protein was present in 96.5%. Podoplanin was observed at the membrane of tumour cells of 94% cases. MMP-9 was found in the cytoplasm tumour cells of 83.7% cases. A high level of expression (67% - 89%) of all four proteins was noted. Podoplanin was associated with the expression of MMP-9 (P=0.010) and both were associated with lymph node metastasis (P=0.011 and P=0.018, respectively). Co-expression of Podoplanin/MMP-9 was an adverse independent prognostic factor for cancer-specific survival (P=0.008) and recurrence-free survival (P=0.042). Podoplanin and MMP-9 together could contribute to tumour progression and dissemination of OSCC. Their combined overexpression showed an adverse effect on survival suggesting th...Continue Reading

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