Prognostic Significance of CHIP and RIPK3 in Non-Small Cell Lung Cancer

Cancers
Jisup KimJoon Seon Song

Abstract

RIPK3 is a key regulator of necroptosis, which plays a double-edged sword role in tumor progression. CHIP is an E3 ubiquitin ligase that regulates necroptosis by degrading RIPK3. Here, we investigated the prognostic value of RIPK3 and CHIP expression in 404 patients with non-small cell lung cancer (NSCLC). Expressions of CHIP and RIPK3 showed opposite correlations with survival. CHIP expression was associated with the longer overall survival (OS), whereas RIPK3 expression was associated with the shorter OS. RIPK3 positivity showed marginal association with shorter OS and disease-free survival (DFS) in adjuvant radiotherapy recipients but not in non-recipients, suggesting that necroptosis may induce radioresistance. In multivariate analysis, CHIP expression was associated with longer OS. Compared with other patients, CHIP(-)/RIPK3(+) patients had shorter OS and DFS. In summary, in patients with NSCLC, the expression of CHIP was an independent favorable prognostic factor while that of RIPK3 was an adverse prognostic factor.

References

Jun 6, 1998·The Journal of Experimental Medicine·D VercammenP Vandenabeele
Feb 8, 2002·Cell·Ricky W JohnstoneScott W Lowe
Jul 12, 2002·Nature·Paola ScaffidiMarco E Bianchi
May 25, 2005·The Journal of Biological Chemistry·Claudia EsserJörg Höhfeld
Jan 5, 2010·Current Opinion in Cell Biology·Dana E Christofferson, Junying Yuan
Sep 9, 2010·Nature Reviews. Molecular Cell Biology·Peter VandenabeeleGuido Kroemer
Feb 18, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kang Won JangSeung Pyung Lim
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jan 31, 2014·The New England Journal of Medicine·Andreas Linkermann, Douglas R Green
May 29, 2014·BioMed Research International·Indranil Paul, Mrinal K Ghosh
Sep 23, 2014·Cell Death and Differentiation·L GalluzziG Kroemer
Jul 2, 2015·Annals of Surgical Treatment and Research·Sang Hun LeeMoo Jun Baek
Dec 15, 2015·Biochimica Et Biophysica Acta·Huan-Tian ZhangChang-Deng Hu
Mar 10, 2016·Oncotarget·Xinjian LiuChuan-Yuan Li
Mar 13, 2016·Biochimica Et Biophysica Acta·Dongshi ChenLin Zhang
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qian TingtingWang ShiLong
Nov 26, 2016·Respiratory Investigation·Kenji MizumuraShu Hashimoto
Apr 30, 2017·Trends in Cancer·Ayaz NajafovJunying Yuan
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tianzhen WangXiaobo Li
Feb 5, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Xia QinZhenyu Cai
Feb 6, 2019·Nature Biotechnology·Cormac Sheridan
May 28, 2019·Molecular Cancer·Yitao GongChen Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
surgical resection
light microscopy

Software Mentioned

Visiopharm
SPSS Statistics
maxstat
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.