Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy

Cardiology Research and Practice
Marcelo Arruda NakazoneReinaldo B Bestetti

Abstract

Few studies regarding chronic kidney disease (CKD) and anemia have been conducted in patients with Chagas cardiomyopathy (CC). We evaluated the risk prediction performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and anemia in CC patients. From 2000 to 2010, a total of 232 patients were studied in a single-center retrospective study. CKD was defined as creatinine clearance <60 mL/min/1.73 m2 according to CKD-EPI equation. Anemia was defined as hemoglobin <12 g/dL (women) and <13 g/dL (men). Cox proportional hazards models were used to establish predictors for death. At baseline, 98 individuals (42.2%) had criteria for CKD and 41 (17.7%) for anemia. During follow-up, 136 patients (58.6%) died. Independently, CKD and anemia were not associated with all-cause mortality. However, when they coexisted, an additional risk was attributed for these patients. Cox proportional hazard models analysis identified systolic blood pressure (hazard ratio, 0.99; 95% confidence interval (CI), 0.98 to 1.00; P=0.015), implantable cardioverter-defibrillator (hazard ratio, 0.48; 95% CI, 0.27 to 0.85; P=0.012), left anterior fascicular block (hazard ratio, 1.52; 95% CI, 1.08 to 2.13; P=0.017), left ventricular end-dia...Continue Reading

References

Feb 1, 1992·American Heart Journal·J ParameshwarP A Poole-Wilson
Nov 1, 1991·Circulation Research·L B TanK T Weber
Feb 7, 1991·The New England Journal of Medicine·H L HaberM Packer
Sep 27, 1984·The New England Journal of Medicine·M R Bristow
Jul 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R N FoleyP E Barre
Oct 10, 1998·Kidney International·M GoicoecheaC Caramelo
Oct 14, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E O'Riordan, R N Foley
Oct 5, 2001·Journal of the American College of Cardiology·A Al-AhmadM J Sarnak
Aug 7, 2002·International Journal of Cardiology·Stefan D Anker, Rakesh Sharma
May 3, 2005·American Heart Journal·Joann Lindenfeld
Feb 8, 2006·Circulation·Hans L HillegeDirk J van Veldhuisen
Aug 12, 2008·International Journal of Cardiology·Reinaldo B Bestetti, Augusto Cardinalli-Neto
Dec 25, 2008·International Journal of Cardiology·Silvia M A FerreiraEdimar A Bocchi
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
May 8, 2010·Journal of Cardiac Failure·Bård WaldumIngrid Os
Jul 2, 2010·International Journal of Cardiology·Reinaldo B BestettiJosé A Cordeiro
Jul 2, 2011·International Journal of Cardiology·André Maurício Souza FernandesRoque Aras Júnior
Oct 28, 2011·Arquivos brasileiros de cardiologia·Amanda Pires BarbosaReinaldo Bulgarelli Bestetti
Mar 1, 2012·International Journal of Cardiology·Luciana G C Vilas BoasPaulo R Nogueira
Mar 8, 2013·International Journal of Cardiology·Abrão AbuhabFernando Bacal
Sep 16, 2017·Journal of the American College of Cardiology·Edimar Alcides BocchiVictor Sarli Issa

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