Prognostic significance of co-existent adenomyosis on outcomes and tumor characteristics of endometrial cancer: A meta-analysis.

The Journal of Obstetrics and Gynaecology Research
Min AnYing Zhang

Abstract

Published data on the impact of co-existent adenomyosis on the prognosis of patients with endometrial cancer remains elusive, with studies reporting conflicting results. We conducted this meta-analysis to evaluate the prognostic significance of co-existent adenomyosis on clinical outcomes and tumor characteristics of endometrial cancer patients. A comprehensive literature review of multiple databases was conducted; quality assessment of eligible studies was performed by the Newcastle-Ottawa scale (NOS). The outcomes of interest were compared in endometrial cancer patients with or without adenomyosis. Hazards ratios (HR) and Odds ratios (OR) with 95% confidence interval (CI) were calculated as a measure of effects. Fourteen retrospective observational studies comprising 1308 endometrial cancer patients with adenomyosis and 3734 patients without adenomyosis were included in this meta-analysis. Results indicated that endometrial cancer patients with adenomyosis was significantly associated with an increased overall survival rate (HR = 0.51; 95% CI = 0.38-0.69; P < 0.00001), but not with disease-free survival rate (HR = 0.68; 95% CI = 0.30-1.53; P = 0.35); besides, significantly associated with decreased ratio of deep myometrial in...Continue Reading

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Citations

Jul 7, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Diego RaimondoRenato Seracchioli

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