PMID: 9428129Jan 1, 1997Paper

Prognostic significance of color Doppler findings in head and neck tumors

Ultrasound in Medicine & Biology
S DelormeG van Kaick

Abstract

We examined whether or not the degree of tumor vascularity in lymph node metastases as depicted by color Doppler is associated with a patient's prognosis. Cervical lymph node metastases in 25 patients with head and neck cancer were examined before combined accelerated radiotherapy and chemotherapy. The findings were quantified using a computer-assisted protocol that quantitatively describes color Doppler images by the relative color pixel density (CPD) and the color hues, which are numerically expressed by the mean color value (MCV). We found that, in the patient group with a CPD below median, the median survival was 958 days and, in the group with a higher CPD, it was 423 days (p = 0.05). The time to detection of distant metastases was 18 months with a low CPD, and 6 months with a high CPD (p = 0.05). However, the time to local or nodal progression was not different between the groups. The MCV was not correlated with prognostic data. These results indicate that, in patients with metastatic head and neck cancer, highly vascularized lymph nodes detected with color Doppler sonography may indicate a shorter survival and earlier occurrence of distant metastases.

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Citations

Jul 13, 2002·Journal of Clinical Ultrasound : JCU·Norbert GritzmannThomas Rettenbacher
Feb 13, 2002·Ultrasound in Medicine & Biology·S DelormeG van Kaick
Feb 8, 2003·European Journal of Ultrasound : Official Journal of the European Federation of Societies for Ultrasound in Medicine and Biology·Rainer GörgesO Dirsch
May 8, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Barbara RöperMichael Molls
Feb 20, 2007·Ultrasound in Medicine & Biology·Johannes ZenkHeinrich Iro
Jan 13, 2005·International Journal of Cancer. Journal International Du Cancer·Thomas ScholbachErcole Di Martino
Mar 31, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·A DietzH Weidauer
Apr 25, 2012·Journal of Indian Association of Pediatric Surgeons·Anand PandeyTej Bali Singh

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