Prognostic significance of combined expression of MUC1 and adhesion molecules in advanced gastric cancer

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Tetsuro OhnoHiroyuki Kuwano

Abstract

The objective of the present study was to evaluate the combination of MUC1 and the status of adhesion molecules in advanced gastric cancers as a possible predictor of patient survival. Two hundred and two paraffin-embedded specimens of gastric carcinoma were examined by immunohistochemical staining using monoclonal antibodies against MUC1 mucin, E-cadherin and beta-catenin. The expression of MUC1 was considered positive if at least 10% of the neoplastic cells were stained. E-cadherin and beta-catenin were classified into four groups. Only a membranous pattern, which was stained as strongly as normal epithelial cells, was judged as normal. The absent pattern (loss of staining), cytoplasmic pattern (cytoplasmic staining with loss of membranous expression), and heterogeneous pattern (cytoplasmic staining with preservation of membranous expression) were considered abnormal. There was a significant relationship between MUC1-positive expression and abnormal expression of E-cadherin (P=0.017). The cancer with abnormal E-cadherin expression or MUC1-positive expression increased, indicating that the cancer invasion was deep. Survival analysis of the outcome revealed that the survival time for those with abnormal E-cadherin/MUC1-positive...Continue Reading

References

Jan 1, 1995·Annual Review of Physiology·S J Gendler, A P Spicer
Sep 1, 1994·Human Pathology·M Pignatelli, C J Vessey
Oct 1, 1996·Glycoconjugate Journal·Y S KimI Brockhausen
Mar 1, 1997·American Journal of Respiratory Cell and Molecular Biology·V ShankarG P Sachdev
Oct 28, 1997·Fertility and Sterility·L LapenséeG Bleau
May 14, 1998·International Journal of Cancer. Journal International Du Cancer·T SuwaK Imai
Aug 12, 1998·International Journal of Cancer. Journal International Du Cancer·C A ReisM Sobrinho-Simões
Aug 18, 2004·Digestive Diseases and Sciences·Belma KocerOmer Cengiz
Sep 21, 2004·World Journal of Gastroenterology : WJG·Hong-Kai ZhangYong-Fen Yi

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Citations

Dec 13, 2006·Molecular Diagnosis & Therapy·Casandra AndersonJoseph Kim
May 17, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Elizabeth G DemiccoMari Mino-Kenudson
Jun 10, 2010·Folia Histochemica Et Cytobiologica·Jolanta CzyzewskaAndrzej Kemona
Jan 22, 2011·World Journal of Gastroenterology : WJG·Stefania NobiliGabriella Nesi
Oct 2, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhan-shan WangJi-kun Li
Jun 25, 2013·Pharmacology & Therapeutics·Marc TänzerMichael Quante
Dec 18, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhi ZengGuo-Hui Fu
May 9, 2014·International Journal of Molecular Sciences·Norihisa SaekiTeruhiko Yoshida
Jun 2, 2009·The Journal of Surgical Research·Zhenglong YuanMaureen A Chung
Sep 25, 2008·Biochemical and Biophysical Research Communications·Xiaolong LiuMaureen Chung
Sep 4, 2007·Biochemical and Biophysical Research Communications·Zhenglong YuanMaureen A Chung
Jun 21, 2015·Pathology, Research and Practice·Carla BartoschIsabel Amendoeira
Nov 6, 2007·Journal of Korean Medical Science·In Mok JungMee Soo Chang
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael S TurnerOlivera J Finn
Nov 2, 2019·Journal of Experimental & Clinical Cancer Research : CR·Zhi-Hong ZongYang Zhao
Dec 9, 2020·Critical Reviews in Oncology/hematology·Zahra Sadat RazaviHamed Mirzaei
May 18, 2021·Indian Journal of Surgical Oncology·Puneet KumarGopeshwar Narayan

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