Prognostic significance of concomitant radiotherapy in newly diagnosed glioblastoma multiforme: a multivariate analysis of 116 patients.

Annals of Saudi Medicine
Nilgun Ozbek OkumusGuzin Gonullu

Abstract

Currently, radiotherapy with concomitant and adjuvant temozolomide has become the standard treatment for glioblastoma. The purpose of this study was to report our experience with radiation plus concomitant temozolomide in 116 patients with glioblastoma multiforme (GBM) and examine the value of different prognostic factors. Retrospective analysis of 116 patients with newly diagnosed GBM, who were treated at our department between January 1994 and March 2009. Age, gender, Karnofsky performance scale (KPS) score, a preoperative history of seizures, extent of surgery, total radiotherapy dose, and use of concomitant and adjuvant temozolomide were evaluated in uni- and multivariate analyses. Survival was determined using the Kaplan-Meier method, and differences were compared using the log rank test. Cox regression analysis was conducted to identify the independent prognostic factors. The median overall survival time was 9 months, and the 1- and 2-year survival rates were 41.9% and 9.6%, respectively. The univariate analysis revealed that age, KPS score, presence of seizures, radiation doses, and use of concomitant and adjuvant temozolomide were significant prognostic factors. The multivariate analysis confirmed that the age, KPS scor...Continue Reading

References

Oct 1, 1979·International Journal of Radiation Oncology, Biology, Physics·M D WalkerG E Sheline
Aug 1, 1990·International Journal of Radiation Oncology, Biology, Physics·P J MillerR G Evans
Apr 16, 1998·International Journal of Radiation Oncology, Biology, Physics·K NakagawaA Akanuma
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roger StuppSerge Leyvraz
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Helen AthanassiouPantelis Karageorgis
Jun 1, 2005·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Stephanie E CombsJürgen Debus
Apr 3, 2007·International Journal of Radiation Oncology, Biology, Physics·Daniela ThorwarthMarkus Alber
Apr 9, 2008·Critical Reviews in Oncology/hematology·Alba A BrandesCharles Vecht
Apr 22, 2008·Neurosurgery·Walter StummerUNKNOWN ALA-Glioma Study Group
May 3, 2008·The Lancet Oncology·Dieta BrandsmaMartin J van den Bent

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Citations

Jan 19, 2018·Neurologia Medico-chirurgica·Mauro DobranMassimo Scerrati
Dec 7, 2016·Molecular Medicine Reports·Yunpeng WangXiaoguang Zhou

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