Prognostic significance of crazy paving ground grass opacities in non-HIV Pneumocystis jirovecii pneumonia: an observational cohort study

BMC Pulmonary Medicine
Shogo KumagaiTadashi Ishida

Abstract

In patients with non-HIV Pneumocystis jirovecii pneumonia (PjP), computed tomography imaging reveals ground grass opacities (GGO). Previous reports show that some patients with non-HIV PjP exhibit GGO with crazy paving. However, there have been no studies on the association between crazy paving GGO and non-HIV PjP clinical outcomes. Here, at the diagnosis of non-HIV PjP, we reviewed high-resolution computed tomography (HRCT) findings that included GGO types and evaluated the prognostic impact of crazy paving GGO on the clinical outcomes of non-HIV PjP immunocompromised patients. We retrospectively reviewed the clinical information including the HRCT findings of patients diagnosed with non-HIV PjP from five institutions between 2006 and 2015. The GGO types included those with or without crazy paving. The associations between clinical factors such as HRCT findings and in-hospital mortality were assessed using the Cox regression model. Sixty-one patients were included in our study. Nineteen patients died at a hospital. All patients exhibited GGO on HRCT imaging at diagnosis of non-HIV PjP. The HRCT findings included crazy paving GGO (29 patients, 47.5%), consolidations (23 patients, 37.7%), bronchiectasis (14 patients, 23.0%), and...Continue Reading

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Citations

Jul 18, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Yingyan ZhengBo Yin
Jul 10, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Yingyan ZhengBo Yin
Jul 6, 2021·Frontiers in Public Health·Yuqiong WangQingyuan Zhan
Jul 15, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Huan-Yi WuYao-Shen Chen
Dec 5, 2021·Clinical Medicine : Journal of the Royal College of Physicians of London·Veronica YioeLisa G Spencer

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Methods Mentioned

BETA
bronchoalveolar lavage
imaging
PCR

Software Mentioned

R

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