Prognostic Significance of Creatinine Increases During an Acute Heart Failure Admission in Patients With and Without Residual Congestion: A Post Hoc Analysis of the PROTECT Data

Circulation. Heart Failure
Marco MetraBeth A Davison

Abstract

The importance of a serum creatinine increase, traditionally considered worsening renal function (WRF), during admission for acute heart failure has been recently debated, with data suggesting an interaction between congestion and creatinine changes. In post hoc analyses, we analyzed the association of WRF with length of hospital stay, 30-day death or cardiovascular/renal readmission and 90-day mortality in the PROTECT study (Placebo-Controlled Randomized Study of the Selective A1 Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized With Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function). Daily creatinine changes from baseline were categorized as WRF (an increase of 0.3 mg/dL or more) or not. Daily congestion scores were computed by summing scores for orthopnea, edema, and jugular venous pressure. Of the 2033 total patients randomized, 1537 patients had both available at study day 14. Length of hospital stay was longer and 30-day cardiovascular/renal readmission or death more common in patients with WRF. However, these were driven by significant associations in patients with concomitant congestion at the time of assessment of renal function. The mean...Continue Reading

References

Apr 1, 1991·Statistics in Medicine·D B Rubin, N Schenker
Jan 13, 2004·Journal of the American College of Cardiology·Daniel E FormanHarlan M Krumholz
Aug 7, 2007·Journal of Cardiac Failure·J Thomas HeywoodUNKNOWN ADHERE Scientific Advisory Committee and Investigators
Oct 10, 2007·Journal of Cardiac Failure·Kevin DammanHans L Hillege
Mar 29, 2008·Journal of the American College of Cardiology·Anju NohriaJames A Hill
Oct 12, 2010·The New England Journal of Medicine·Barry M MassieUNKNOWN PROTECT Investigators and Committees
Dec 15, 2010·The American Journal of Cardiology·David E LanfearL Keoki Williams
Jan 21, 2011·The American Journal of Cardiology·Tobias BreidthardtChristian Mueller
Nov 12, 2013·Circulation. Heart Failure·Meredith A BriscoJeffrey M Testani
Nov 28, 2013·Circulation. Heart Failure·Michael M GivertzAdriaan A Voors
Mar 4, 2014·European Heart Journal·Mattia A E ValenteHans L Hillege
Oct 8, 2014·European Journal of Heart Failure·Adriaan A VoorsUNKNOWN RELAX-AHF Investigators
Apr 4, 2015·European Heart Journal·Kevin Damman, Jeffrey M Testani

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Citations

May 22, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Navin K KapurDaniel Burkhoff
Nov 9, 2019·Heart Failure Reviews·Gaetano RuoccoJozine M Ter Maaten
Nov 28, 2019·Journal of Cardiovascular Translational Research·Navin K KapurRichard H Karas
Dec 5, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Bhagwan DassRajesh Mohandas
Sep 2, 2020·Journal of Nephrology·Giacomo DeferrariEdoardo La Porta
Mar 15, 2019·Scientific Reports·Satoshi HiguchiHideaki Yoshino
Nov 27, 2019·European Journal of Heart Failure·Nicholas WetterstenAlan Maisel
Sep 11, 2020·Current Cardiology Reports·W H Wilson Tang, Alan Kiang
Feb 15, 2019·Current Heart Failure Reports·Richa GuptaSean Collins
Oct 17, 2021·European Journal of Heart Failure·Pieter Martens
Nov 18, 2021·European Journal of Heart Failure·Johanna E EmmensJohn R Teerlink

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