PMID: 9538120Jun 6, 1998Paper

Prognostic significance of cyclin expression in human osteosarcoma

International Journal of Oncology
L MolendiniP Picci

Abstract

To evaluate the distribution of cyclin protein expression, in relation to cell proliferation rate and clinical behavior, an immunohistochemical study was performed on 92 tumor samples of patients with high grade osteosarcoma (OS). A large cyclin A- and cyclin E-positive fraction was found respectively in 59% and 47% of the osteosarcomas, while immunostaining for cyclin D1 was weak or absent in most tumor samples. A positive, statistically significant correlation was found between A and E cyclins and Ki67 expression (p<0.001). Disease-free survival (DFS) analysis included 69 of the 92 patients. A significantly higher probability of metastasis was seen in patients lacking cyclin D1 compared to those in which cyclin D1 was positive (p<0.01). Conversely, patients with >40% of cyclin A-positive cells relapsed more frequently than those with <40% of cyclin A-positive cells (p<0.05). The multivariate analysis demonstrated that cyclin A had a lower predective risk in terms of disease-free survival as opposed to the loss of cyclin D1 that is considered a powerful prognostic factor.

Citations

Jul 30, 2003·Cancer Genetics and Cytogenetics·Avery A Sandberg, Julia A Bridge
May 19, 2004·The International Journal of Biochemistry & Cell Biology·Tarik Möröy, Christoph Geisen
Feb 6, 2003·International Journal of Cancer. Journal International Du Cancer·Fredrik ErlandssonAnders Zetterberg
Feb 26, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Wenxi YuZan Shen
Apr 20, 2005·Oncogene·Harry C Hwang, Bruce E Clurman
Mar 13, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ran WeiZhenfeng Duan
Sep 25, 2020·Aging·Ce ShiXiao-Zhong Zhou

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