Prognostic significance of DAPK and RASSF1A promoter hypermethylation in non-small cell lung cancer (NSCLC)

Folia Histochemica Et Cytobiologica
Wieslawa NiklinskaRobert Milewski

Abstract

The epigenetic inactivation of tumor suppressor genes may play an important role in the development and progression of many cancer types, including lung cancer. Therefore, we investigated the association between the aberrant promoter methylation of 2 genes: the Death-Associated Protein Kinase (DAPK) and the Ras Association Domain Family 1A (RASSF1A) by using methylation-specific PCR, and the clinicopathological features and prognosis in 70 radically resected non-small cell lung cancers (NSCLCs). Hypermethylation of the DAPK and RASSF1A promoters was found in 24 (34%), and in 18 (26%) tumor DNA samples, respectively. Regarding different clinicopathological features of NSCLCs, the DAPK promoter methylation was more frequently observed in squamous cell carcinoma (46%) than in adenocarcinoma (25%) and large cell carcinoma (22%), but there were no significant statistical differences (p=0.3). On the other hand, a statistically significant trend was observed between the RASSF1A methylation and a histological type of tumor (p=0.06). 45% of adenocarcinoma tumors showed RASSF1A promoter methylation in comparison to 17% of squamous cell carcinomas and 22% of large cell carcinomas. When both markers were analyzed according to the tumor-nod...Continue Reading

References

Jan 1, 1991·The British Journal of Clinical Practice·J E Dussek
Sep 1, 1991·Chest·M S Bains
Sep 1, 1991·Critical Reviews in Oncology/hematology·C F Moutain
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
May 3, 2001·Journal of the National Cancer Institute·D G BurbeeJ D Minna
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·W NiklińskaJ Nikliński
May 25, 2002·Molecular and Cellular Biology·Latha ShivakumarMichael A White
Jun 10, 2003·International Journal of Cancer. Journal International Du Cancer·Hideki EndohTetsuya Mitsudomi
Oct 7, 2003·Oncogene·Richard L Momparler
Jul 22, 2004·British Journal of Cancer·S ToyookaA F Gazdar
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jie WangLi Mao
Nov 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yoshio TomizawaMasatomo Mori
Nov 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles LuFadlo R Khuri
Jul 2, 2005·Expert Opinion on Emerging Drugs·M S Wallace
Nov 1, 2005·The Journal of Thoracic and Cardiovascular Surgery·Young Tae KimJoo Hyun Kim
Jul 4, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Naoki YanagawaTeiichi Motoyama

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Citations

Oct 23, 2012·Molecular Biology Reports·Ewa BrzeziańskaAdam Antczak
Oct 15, 2011·American Journal of Respiratory Cell and Molecular Biology·Sigal NakavRonen Alon
Dec 7, 2013·Apoptosis : an International Journal on Programmed Cell Death·Yide HuangYao Lin
Mar 26, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Rejane Hughes CarvalhoSjaak Philipsen
Apr 2, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Scott M LangevinKarl T Kelsey
Jun 28, 2013·PloS One·Xiang-Bin XingMin-Hu Chen
Jan 1, 2013·Cells·Eric HervouetPierre-François Cartron
Jul 15, 2015·British Journal of Cancer·A M Grawenda, E O'Neill
Apr 9, 2020·Journal of Cancer Research and Clinical Oncology·Nanhong LiJian Huang
May 6, 2015·Cancer Metastasis Reviews·Aditi MehtaGuillermo Barreto
Aug 28, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·T PowrózekJ Milanowski
Apr 20, 2019·Biomolecules·Qingshui WangYao Lin
Jul 3, 2021·Cancers·Ezgi Ozyerli-Goknar, Tugba Bagci-Onder
Dec 23, 2021·The International Journal of Biological Markers·Zhimao ChenShijie Zhang

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