Prognostic significance of depth of gross or microscopic perirectal fat invasion in T3 N0 M0 rectal cancers following sharp mesorectal excision and no adjuvant therapy

International Journal of Colorectal Disease
Antonio I PiconJosé G Guillem

Abstract

Although the standard of care for T3 and/or N1-2 rectal cancers includes adjuvant chemoradiation, it is unclear whether T3 N0 patients with limited microscopic perirectal fat invasion warrant further therapy. Our aim was to determine the prognostic significance of gross perirectal fat invasion, or depth of microscopic perirectal fat invasion, in T3 N0 rectal cancers following sharp mesorectal excision and no adjuvant therapy. Utilizing a prospective database, the medical records of 108 patients who underwent a potentially curative resection for T3 N0 rectal cancer between June 1986 and December 1994 were analyzed. All pathological specimens were re-reviewed by a single pathologist, and extent of perirectal fat invasion was measured in millimeters. Patients who received either preoperative or postoperative adjuvant therapy were excluded. Macroscopic perirectal fat invasion (T3 gross) was present in 49 cases, absent in 40 cases (T3 microscopic), and not reported in 19 cases. Rectal cancers were stratified by extent of measured perirectal fat invasion into 3 mm or less and more than 3 mm. Five-year overall and local recurrence rates for the entire group were 19% and 8%, respectively. The disease-free survival, disease-specific sur...Continue Reading

Citations

Oct 26, 2011·Southern Medical Journal·Karl MrakJörg Tschmelitsch
Feb 2, 2012·Chemotherapy Research and Practice·Ingrid GarajováGiovanni Brandi
May 3, 2011·World Journal of Radiology·Charles F BellowsGuiseppe Gagliardi
May 23, 2014·AJR. American Journal of Roentgenology·Seung Hyun ChoUNKNOWN Society of North America (RSNA)
Dec 17, 2009·Annals of Surgical Oncology·Raffaele LombardiBruno Cola
Nov 13, 2013·International Journal of Clinical Oncology·Deniz TuralSüheyla Serdengeçti
Nov 26, 2013·Surgical Oncology Clinics of North America·P Terry Phang, Xiaodong Wang
Jun 8, 2011·Seminars in Radiation Oncology·Jennifer Y WoTheodore S Hong
Feb 26, 2015·Surgery Today·In Ja ParkJin Cheon Kim
Aug 24, 2013·Journal of Surgical Oncology·Yoshito AkagiTetsushi Kinugasa
Oct 26, 2011·International Journal of Cancer. Journal International Du Cancer·Yoshito AkagiUNKNOWN Study Group of the Japanese Society for Cancer of the Colon and Rectum (JSCCR) on the Clinical Significance of the Mesorecta
Dec 4, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hagen KenneckeBalvinder Johal
Jul 21, 2012·Journal of the Korean Society of Coloproctology·Hong Yeol YooJae-Gahb Park
Jul 2, 2016·Clinical Colorectal Cancer·Leonardo S Lino-SilvaÁngel Herrera-Gómez
Feb 3, 2009·The Surgical Clinics of North America·Kenneth L MeredithDavid Shibata
Nov 29, 2007·Surgical Oncology·Riccardo RosatiNiccolò Furlan
Jan 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·José G GuillemSalvatore Pucciarelli
Nov 25, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R ZinicolaR J Nicholls
Jul 8, 2009·Diseases of the Colon and Rectum·Kirsten M BoyleDermot Burke
Apr 3, 2020·American Journal of Clinical Oncology·Nina N SanfordMichael R Folkert
Nov 9, 2012·Diseases of the Colon and Rectum·Rumi ShinJae-Gahb Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Werner HohenbergerJ Göhl
International Journal of Cancer. Journal International Du Cancer
Yoshito AkagiStudy Group of the Japanese Society for Cancer of the Colon and Rectum (JSCCR) on the Clinical Significance of the Mesorecta
Zeitschrift für Gastroenterologie
C PoxDeutschen Krebshilfe e. V
© 2022 Meta ULC. All rights reserved