Prognostic significance of elevated serum CD44 levels in patients with oral squamous cell carcinoma

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Sharada SawantDevendra Chaukar

Abstract

Availability of reliable methods distinguishing high-risk recurrent tumours from regressive tumours prior to surgery could help in better management of the disease. This study was aimed to estimate pre-surgical serum CD44 concentration and assess the possibility of using it as a non-invasive prognostic tool in oral cancer. ELISA was performed on pre-surgical serum samples from 64 primary oral cancer patients and 16 healthy individuals to estimate soluble CD44 levels. Immunohistochemistry was performed on parallel 64 solid tumours and 10 recurrent tumours. All patients clinically followed up for median period of 19.2 months and obtained prognostic information correlated with CD44 concentration in serum as well as in tumours. Serum CD44 concentration was found significantly high in patients as compared to healthy individuals (P < .001) and also in patients whose disease locally recurred as compared to those did not recur (P = 0026). High serum CD44 concentration inversely affected on patients survival (P = .032). CD44v6 staining intensity was detected significantly high in recurrent tumours as compared to primary tumours (P < .001), and it also correlated with poor survival (P < .001). Furthermore, in combination, patients with i...Continue Reading

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Citations

Jul 11, 2019·Proteomics. Clinical Applications·Marija GrozdanićMarko Fonović
Aug 3, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chui S ChuSiu-Wai Choi
Feb 26, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vinata B LokeshwarBal L Lokeshwar
Dec 12, 2020·Experimental Hematology & Oncology·Hanxiao XuAiguo Liu
Jun 25, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Erin R CohenElizabeth J Franzmann

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