Prognostic significance of endoscopic ultrasound-defined pleural, pericardial or peritoneal fluid in oesophageal cancer.

Surgical Endoscopy
Christopher P TwineW G Lewis

Abstract

Endoscopic ultrasound (EUS) is known to detect smaller effusion volumes than computerised tomography (CT), yet the outcomes for patients diagnosed with oesophageal carcinoma and EUS-defined pleural, pericardial or ascitic fluid effusions (EDFE) are unknown. The aim of this study was to determine the outcome of multidisciplinary stage directed treatment for such patients. Forty-nine (9.2%) out of a consecutive 527 patients diagnosed with oesophageal cancer from a single regional upper gastrointestinal (GI) cancer network were found to have evidence of EDFE undetected by CT. Thirty-nine (79.6%) patients had pleural effusions, eight (16.3%) pericardial effusions, and two (4.1%) ascites. Twelve (24.4%) underwent surgery, 3 (6.1%) received neoadjuvant chemotherapy without subsequent surgery, 12 (24.5%) received definitive chemoradiotherapy (dCRT), and 22 (44.9%) received palliative treatment. Survival in patients with EDFE was significantly shorter (median and 2-year survival 15.6 months and 24%, respectively) when compared with patients without EDFE (26.7 months and 40%, respectively, p = 0.001), and was unrelated to EDFE type (p = 0.192). Two-year survival after oesophagectomy with or without neoadjuvant therapy was 45% in patient...Continue Reading

References

Apr 1, 1997·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·G BalzanoV Di Carlo
Jan 23, 1998·Cancer·A A RenshawS Swanson
Apr 19, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·D J BowreyP D Carey
Jun 7, 2002·Lancet·UNKNOWN Medical Research Council Oesophageal Cancer Working Group
Jan 1, 1964·The British Journal of Surgery·G B ONG
Jan 8, 2004·British Journal of Cancer·T D L CrosbyT S Maughan
Oct 27, 2004·The British Journal of Surgery·O A KhanF D Beggs
Mar 4, 2005·The American Journal of Gastroenterology·Gregory ZuccaroEugene H Blackstone
Oct 8, 2005·Surgical Endoscopy·X ZhangJ R Bessell
May 26, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M R StephensK Shute
Dec 5, 2006·Gastrointestinal Endoscopy·Neeraj KaushikKevin McGrath
Mar 6, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·John DeWittStuart Sherman
Apr 20, 2007·The British Journal of Surgery·A A Al-SariraD J Corless
May 19, 2007·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M A MorganG W B Clark

❮ Previous
Next ❯

Citations

Jul 16, 2010·Gastrointestinal Endoscopy·Alberto LarghiGuido Costamagna
Sep 12, 2009·Best Practice & Research. Clinical Gastroenterology·M Polkowski
Feb 26, 2014·World Journal of Gastrointestinal Endoscopy·Rei SuzukiHiromasa Ohira
Jun 20, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Surinder Singh RanaRajesh Gupta
Aug 19, 2014·World Journal of Gastroenterology : WJG·Marissa M Montgomery, I Michael Leitman
Nov 23, 2019·The Thoracic and Cardiovascular Surgeon·Rebecca Grossman, Rohin Francis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.