Prognostic significance of Fas (CD95/APO-1) positivity in patients with primary nodal diffuse large B-cell lymphoma

American Journal of Hematology
Bulent EserAli Unal

Abstract

Fas (CD95/APO-1) is a protein that is mainly related to apoptosis of lymphoid cells. The increment of Fas expression is associated with long-term survival in various malignancies. However, there are limited studies regarding the effect of Fas expression on the course and prognosis of non-Hodgkin's lymphoma. The aim of this study was to investigate the significance of immunohistochemical Fas expression on the prognosis of nodal diffuse large B-cell lymphoma. A total of 63 patients with primary nodal diffuse large B-cell lymphoma diagnosed in the Erciyes University Department of Hematology between 1990 and 2003 were included in the study. The median age of the patients was 55 years old (range 19-102 years old). The median follow-up period was 19 months (2-132 months). Histopathological sections were stained immunohistochemically and evaluated by light microscopy for Fas, bcl-2, and p53. Clinical and laboratory parameters including Fas, bcl-2, and p53 positivity, age, sex, performance status, clinical stage, presence of B symptoms, bone marrow involvement, extranodal involvement, and lactic dehydrogenase levels were evaluated to compare overall survival. Complete remission was obtained in 28 patients (44.4%) after first-line chemo...Continue Reading

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Citations

Apr 17, 2010·Molecules and Cells·E ShunmeiJiangying Zou
Mar 9, 2007·Immunology·Naama Peshes-YalozGideon Berke
Feb 7, 2015·Cell Death and Differentiation·M E PeterP Ceppi
May 17, 2017·Cytometry. Part B, Clinical Cytometry·Chandra Chiappin CardosoMaria Claudia Santos-Silva
Oct 5, 2006·American Journal of Hematology·Victor Piana de Andrade, Fernando Augusto Soares

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