Prognostic significance of grading based on the counting of poorly differentiated clusters in colorectal mucinous adenocarcinoma

Human Pathology
Valeria BarresiGiovanni Tuccari

Abstract

Mucinous adenocarcinoma (MAC) of the colon and rectum is a histological entity with still indefinite prognostic significance. Although it was previously designated as poorly differentiated by convention, the most recent World Health Organization guidelines indicate that the level of maturation of the epithelium determines differentiation in MAC and that microsatellite instability status should be taken into account for its histological grading. Nonetheless, precise criteria for grading are not provided, and the prognostic value of histological grading in MAC still remains unclear. In the present study we aimed to investigate the prognostic value of a grading system based on the counting of poorly differentiated clusters (PDC) of neoplastic cells in 108 colorectal MACs and to compare its reproducibility and significance with those of a grading system based on glandular differentiation. We found that PDC grade was more reproducible and significantly associated with disease progression (P = .0089) as well as with death from colorectal cancer (P = .0035) in our MACs, as compared to the grade based on glandular differentiation, which was not associated with any of the clinicopathologic variables. Moreover, PDC grade emerged as a sig...Continue Reading

References

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Citations

Jul 23, 2016·Clinical Colorectal Cancer·Valeria BarresiGiovanni Tuccari
Nov 14, 2019·Journal of Pathology and Translational Medicine·Baek-Hui KimYoun Wha Kim
Jan 17, 2020·The Oncologist·Gerardo RosatiUNKNOWN TOSCA (Three or Six Colon Adjuvant) Investigators
Sep 12, 2019·Archives of Pathology & Laboratory Medicine·Catherine E Hagen, Ayesha Farooq
Mar 24, 2016·Diagnostic Pathology·Luca Reggiani BonettiCristian Palmiere
Jul 11, 2016·Virchows Archiv : an International Journal of Pathology·Valeria BarresiLuigi Baron
Feb 23, 2021·Journal of Cancer Research and Clinical Oncology·Elmira GheytanchiZahra Madjd

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