Prognostic significance of HER3 and HER4 protein expression in colorectal adenocarcinomas

BMC Cancer
Panteleimon KountourakisTheofanis Economopoulos

Abstract

Colorectal cancer remains a major cause of cancer mortality in the Western world. A limited number of studies has been conducted in respect of Her-3 and Her-4 expression and their correlation with clinical parameters and prognosis in colorectal carcinomas . In this study we sought to determine the pattern and the prognostic significance of HER-3 and HER-4 in colorectal adenocarcinoma. We studied HER-3 and HER-4 protein expression in106 paraffin embedded specimens of primary colorectal tumors using immunohistochemistry. The pattern and protein expression levels of HER-3 and HER-4 were correlated with several clinical and pathological parameters. HER-3 staining displayed membranous and cytoplasmic expression pattern in 18 (17%) and 30 samples (28,3%), respectively. HER-4 membranous and cytoplasmic expression was found in 20 (18,9%) and 32 samples (30,2%), respectively. Specimens regarded as positive for HER-3 cytoplasmic expression were associated with moderate tumor grade (p = 0,032) and older median age (p = 0,010). Specimens regarded as positive for HER-4 membranous protein expression were associated with involved lymphnodes (p = 0,0003). Similar results were obtained when considering Her-3 and Her-4 protein expression irrespe...Continue Reading

References

Dec 15, 1989·International Journal of Cancer. Journal International Du Cancer·C R De PotterH Roels
Jul 1, 1995·Critical Reviews in Oncology/hematology·D S SalomonN Normanno
Sep 1, 1994·Journal of Clinical Pathology·E W KayM Leader
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M E van der BurgJ G Klijn
May 1, 1997·Cancer Treatment Reviews·R S Midgley, D J Kerr
Feb 9, 1999·Lancet·R Midgley, D Kerr
Aug 25, 1999·Lancet·I Maghfoor
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T W JacobsS J Schnitt
Feb 25, 2000·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·I PorebskaT Bojarowski
Aug 28, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S MénardE Tagliabue
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y Yarden
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L VogelMichael Press
May 15, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J C LeeH-B Yang
May 27, 2003·International Journal of Cancer. Journal International Du Cancer·Daniel R NathansonPhilip B Paty
Dec 30, 2003·International Journal of Cancer. Journal International Du Cancer·Elizabeth HalfFrank A Sinicrope
May 15, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Akishi OoiYoh Dobashi
Feb 19, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P Boyle, J Ferlay
May 9, 2009·International Journal of Molecular Medicine·M L Dos SantosM A Nagai

❮ Previous
Next ❯

Citations

Apr 25, 2009·International Journal of Colorectal Disease·Glauco BaiocchiWilson T Nakagawa
Mar 5, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Alexandre Andrade Anjos JácomeJosé Sebastião Santos
Jan 10, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jörgen Carlsson
Apr 12, 2008·Cancer Gene Therapy·G Sithanandam, L M Anderson
Dec 1, 2012·Chemotherapy Research and Practice·Ning JiangZhuo Georgia Chen
Nov 1, 2008·Cancer Research·Deborah W NeklasonRandall W Burt
Feb 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marcia R CampbellMark M Moasser
Aug 2, 2011·Journal of Translational Medicine·Mikiko TakikitaStephen M Hewitt
Nov 21, 2008·Breast Cancer Research : BCR·Amy J Jackson-FisherDavid F Stern
Jan 4, 2008·Annals of Surgical Oncology·Qichun WeiJorgen Carlsson
Dec 22, 2009·Future Oncology·Maija Hollmén, Klaus Elenius
Nov 25, 2014·BMC Cancer·Keigo MitsuiChoitsu Sakamoto
Feb 11, 2016·Acta Oncologica·Frida LédelDavid Edler
Jan 26, 2010·Expert Opinion on Investigational Drugs·Muhammad W Saif
Jan 16, 2013·Expert Opinion on Investigational Drugs·Monica Dandona DesaiAlbert Craig Lockhart
Mar 6, 2015·Virchows Archiv : an International Journal of Pathology·An Na SeoHye Seung Lee
Aug 12, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Abd AlRahman M FodaAsmaa I Gado
Dec 12, 2012·Journal of the National Cancer Institute·Alberto OcanaEitan Amir
Oct 18, 2011·Expert Review of Anticancer Therapy·Paul H S Shaw, Richard A Adams
Oct 12, 2012·Virchows Archiv : an International Journal of Pathology·Hee Jin LeeSeung-Mo Hong
Mar 18, 2020·Acta Biochimica Et Biophysica Sinica·Xiaodong LiJianhua Lin
Oct 31, 2015·Oncotarget·Yadong WangGuangcai Duan
Nov 18, 2014·Oncotarget·Kalpana MujooZhiqiang An
Apr 29, 2015·Oncotarget·Hanna StyczenLena-Christin Conradi
Aug 15, 2012·Oncotarget·Luigi AurisicchioGennaro Ciliberto
Jul 16, 2014·International Journal of Oncology·Susumu NakataHayao Nakanishi
Mar 29, 2020·Cellular Oncology (Dordrecht)·Vincent F M SegersGilles W De Keulenaer
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mikiko HayashiKenichi Sugihara
Mar 7, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew G HillJosep Tabernero
Jan 18, 2011·Journal of Comparative Pathology·A R DosterJ-H Sur
Apr 21, 2019·International Journal of Biological Macromolecules·Ayub KarimzadehNasrin Shadjou
Dec 2, 2008·Experimental Cell Research·William H FiskeRobert J Coffey
Sep 20, 2011·Clinical Colorectal Cancer·Marc PeetersJean-Yves Douillard

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Methods Mentioned

BETA
surgical
biopsy
light microscopy

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