PMID: 11904025Mar 21, 2002Paper

Prognostic significance of hypernatremia and hyponatremia among patients with aneurysmal subarachnoid hemorrhage

Neurosurgery
Adnan I QureshiL Nelson Hopkins

Abstract

Abnormal serum sodium levels (hyponatremia and hypernatremia) are frequently observed during the acute period after aneurysmal subarachnoid hemorrhage (SAH) and may worsen cerebral edema and mass effect. We performed this study to determine the prognostic significance of serum sodium concentration abnormalities. We analyzed prospectively collected data for the placebo treatment group in a clinical trial conducted at 54 neurosurgical centers in North America. The presence of hypernatremia (serum sodium concentration of >145 mmol/L) and hyponatremia (serum sodium concentration of <135 mmol/L) was determined with serum sodium measurements obtained at admission and 3, 6, and 9 days after SAH. The effects of hypernatremia and hyponatremia on the risk of symptomatic vasospasm and on 3-month outcomes were analyzed after adjustment for the following potential confounding factors: age, sex, preexisting hypertension, admission Glasgow Coma Scale score, initial mean arterial pressure, subarachnoid clot thickness, intraventricular blood or intraparenchymal hematoma, ventricular dilation, and aneurysm size and location. Of 298 patients in the analysis, 58 (19%) developed hypernatremia and 88 (30%) developed hyponatremia. Hypernatremia was s...Continue Reading

References

Mar 1, 1975·Lancet·B Jennett, M Bond
Dec 1, 1992·Clinical Neuropharmacology·M N Diringer
Sep 1, 1989·Stroke; a Journal of Cerebral Circulation·D HasanM Vermeulen
Aug 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·L DisneyP Roberts
Nov 1, 1989·Stroke; a Journal of Cerebral Circulation·D HasanJ van Gijn
Jun 1, 1986·Journal of Neurochemistry·Q R Smith, S I Rapoport
Jul 13, 1974·Lancet·G Teasdale, B Jennett
Aug 1, 1972·Journal of Neurosurgery·A M LandoltH Krayenbühl
Oct 1, 1983·Journal of Neurochemistry·A L Betz
May 22, 1998·Stroke; a Journal of Cerebral Circulation·F H VermeijC J Avezaat

❮ Previous
Next ❯

Citations

Dec 25, 2008·QJM : Monthly Journal of the Association of Physicians·B WhelanB Silke
Oct 5, 2010·Neurologia Medico-chirurgica·Hirotoshi Sano, Sachin Mahajan
Dec 24, 2010·Current Opinion in Critical Care·Katja E Wartenberg
Nov 3, 2012·Neurosurgical Focus·Judith M WongAtul A Gawande
Dec 6, 2012·Neurocritical Care·Matthew A KirkmanDoris Doberenz
Feb 15, 2017·European Journal of Endocrinology·Aoife GarrahyChristopher J Thompson
May 16, 2018·Journal of Intensive Care·Tomoya Okazaki, Yasuhiro Kuroda
Jan 15, 2019·Pituitary·Zuleyha KaracaFahrettin Kelestimur
Dec 27, 2019·Clinical and Experimental Pharmacology & Physiology·Marta AleksandrowiczEwa Kozniewska
Mar 18, 2006·Current Opinion in Critical Care·Katja E Wartenberg, Stephan A Mayer
Feb 21, 2006·Clinical Endocrinology·Mark SherlockChristopher J Thompson
May 12, 2006·The Neurologist·Michael N Diringer, Allyson R Zazulia
Aug 12, 2005·Neurosurgery·Wouter Jan SchuilingGabriël J E Rinkel
Jan 6, 2009·Neurocritical Care·Theresa MurphyMichael Diringer
Feb 14, 2012·Journal of Intensive Care Medicine·Deborah M GreenChristina M DeFusco
Jul 13, 2011·Neurocritical Care·Alejandro A Rabinstein, Nicolas Bruder
Sep 8, 2012·Der Anaesthesist·P KellnerC Raspé
Sep 25, 2015·British Journal of Neurosurgery·Vera SpatenkovaPavel Skrabalek
Oct 1, 2018·Clinical Endocrinology·Aoife GarrahyChristopher J Thompson
May 11, 2019·Acta neurochirurgica·Khandkar Ali KawsarColin Watts
Mar 8, 2006·Critical Care Medicine·Katja E WartenbergStephan A Mayer
Jun 12, 2004·Neurosurgical Focus·Chad D ColeWilliam T Couldwell
Oct 30, 2008·Current Neurology and Neuroscience Reports·Joshua M Levine
Jul 31, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·W-H LimP-H Yang
Feb 13, 2009·Current Treatment Options in Neurology·Joshua M Levine
Oct 17, 2009·Neurosurgery·Maryam Rahman, William A Friedman
May 6, 2015·Journal of Clinical Medicine·Neena I Marupudi, Sandeep Mittal
Jun 1, 2012·Annals of Intensive Care·Charalampos PierrakosSerge Brimioulle
Jun 2, 2016·British Journal of Neurosurgery·Inga Chen, Patrick Mitchell
Nov 2, 2017·Neurosurgical Focus·Aditya VedantamShankar P Gopinath
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Gabriel J E Rinkel
Mar 18, 2008·Arquivos de neuro-psiquiatria·Eliane de Araújo CintraRenato G G Terzi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Arrhythmogenic Right Ventricular Dysplasia

Arrhythmogenic right ventricular dysplasia is a congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the right ventricle wall and loss of myocardial cells. Primary injuries usually are at the free wall of the right ventricular and right atria resulting in ventricular and supraventricular arrhythmias. Discover the latest research on arrhythmogenic right ventricular dysplasia here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Magnesium Research : Official Organ of the International Society for the Development of Research on Magnesium
George K C WongChristopher W Lam
Clinical Nephrology
R M FriedlerK Kurokawa
Emergency Medicine Clinics of North America
T Janz
Emergency Medicine Clinics of North America
Michelle LinIngrid T Lim
© 2022 Meta ULC. All rights reserved