Aug 21, 1976

Prognostic significance of in-vitro complement fixation in liver biopsy specimens from patients with acute viral hepatitis type B

M RizzettoG Verme


The prognostic significance of in-vitro complement fixation (V.C.F.) by hepatitis-B core antigen/antibody immunocomplexes in hepatitis-B surface antigen (HBsAg) positive liver biopsy specimens was prospectively evaluated in 47 patients presenting with acute viral hepatitis type B. 34 of 37 V.C.F.-negative patients made an uneventful recovery and became HBsAg negative; in all patients with a V.C.F.-positive test chronic hepatitis and persistent antigenaemia developed. The V.C.F. test is a simple and reliable prognostic indicator of persistent infection and of progression of apparently acute hepatitis to a chronic liver disorder.

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Mentioned in this Paper

End Stage Liver Disease
Acute Disease
Hepatitis B antigen peptide
Persistent Infection
Liver Diseases
Hepatitis B Surface Antigens
Immune complex
Hepatitis B Surface Antigen Measurement

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