Prognostic significance of interictal epileptiform discharges after epilepsy surgery

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
Chaturbhuj Rathore, Kurupath Radhakrishnan

Abstract

The prognostic significance of interictal epileptiform discharges (IED) after epilepsy surgery is uncertain. We reviewed 20 studies (including 2 unpublished data sets) to assess the usefulness of postoperative EEG findings in predicting seizure outcome after resective epilepsy surgery. Patient selection and methodology varied widely among the studies. The published studies included 1,345 patients (temporal resection, n = 751; extratemporal resection, n = 373; unspecified site, n = 221). We defined a favorable outcome as a postoperative seizure status of Engel class I or equivalent. The frequency of postoperative IED ranged from 13% to 68% (mean, 31.5%). Postoperative IED were strongly associated with an unfavorable seizure outcome for the whole cohort (odds ratio, 3.3; 95% confidence interval, 2.5-4.5), for the subgroup of patients who underwent temporal resection (odds ratio, 2.5; 95% confidence interval, 1.6-4.0), and for the extratemporal resection subgroup (odds ratio, 5.6; 95% confidence interval, 3.9-9.3). Postoperative IED had a modest positive predictive value (52%) but an excellent negative predictive value (71%) for unfavorable seizure outcome. Most IED (>90%) were localized to the site of resection and were also infl...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Apr 1, 1995·Electroencephalography and Clinical Neurophysiology·L CarmantG L Holmes
Mar 1, 1995·Epilepsia·S PatrickS S Spencer
Jun 1, 1993·The Japanese Journal of Psychiatry and Neurology·T MatsuzakaS Sugai
Apr 23, 1993·Brain Research·L SvenssonJ A Engel
Jul 18, 2000·Epilepsia·R K MosewichP C O'Brien
Aug 28, 2001·Brain : a Journal of Neurology·F Rosenow, H Lüders
Oct 8, 2003·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Gudrun GröppelChristoph Baumgartner
Dec 25, 2003·Neurology·S S SpencerUNKNOWN Multicenter Study of Epilepsy Surgery
Mar 11, 2004·Seizure : the Journal of the British Epilepsy Association·J JanszkyA Ebner
Apr 7, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Giancarlo Di GennaroGiampaolo Cantore
May 18, 2004·Epilepsia·Heinz-Gregor Wieser, UNKNOWN ILAE Commission on Neurosurgery of Epilepsy
Jun 25, 2004·Brain : a Journal of Neurology·Anne M McIntoshSamuel F Berkovic
Sep 6, 2005·Seizure : the Journal of the British Epilepsy Association·Michelle HildebrandtAlois Ebner
Jan 9, 2007·Brain : a Journal of Neurology·Lara E JehaHans Lüders
May 18, 2007·Brain & Development·Chaturbhuj RathoreKurupath Radhakrishnan
Jun 10, 2008·Epilepsy Research·Alaa Eldin ElsharkawyAlois Ebner
Sep 25, 2008·Neurosurgery·Alaa E ElsharkawyAlois Ebner
Oct 25, 2008·Seizure : the Journal of the British Epilepsy Association·Georges A GhacibehStephan Eisenschenk
Nov 26, 2008·Journal of Neurosurgery·Alaa Eldin ElsharkawyAlois Ebner
Mar 28, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·A E ElsharkawyA Ebner
Aug 1, 1961·Journal of Neurology, Neurosurgery, and Psychiatry·J McFie

❮ Previous
Next ❯

Citations

Oct 1, 2011·Epilepsia·Rani A SarkisWilliam E Bingaman
Mar 1, 2012·Epilepsy Currents·Bassel W Abou-Khalil
Feb 26, 2013·Seizure : the Journal of the British Epilepsy Association·Anke M StaackBernhard J Steinhoff
Jun 22, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Giancarlo Di GennaroAngelo Picardi
Mar 18, 2015·Expert Review of Neurotherapeutics·Felix RosenowHajo M Hamer
Feb 4, 2021·Clinical Neurophysiology Practice·Maxime O BaudVikram R Rao
Aug 6, 2021·Epilepsy & Behavior : E&B·Jafar Mehvari HabibabadiNasim Tabrizi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.