Prognostic significance of interictal epileptiform discharges in newly diagnosed seizure disorders

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
E C Wirrell

Abstract

EEGs performed for new-onset seizures show epileptiform discharge in approximately 18% to 56% of children and 12% to 50% of adults. An EEG after sleep deprivation improves detection of epileptiform abnormalities, showing discharge in 13% to 35% of patients whose standard EEG findings were normal. Some studies have also shown a higher yield with EEG performed within 24 hours after the seizure. The EEG is a useful diagnostic study in this clinical setting for a number of reasons. First, specific EEG abnormalities help characterize the seizure type and epilepsy syndrome, which allows more informed decisions regarding therapy and more accurate prediction of seizure control and ultimate remission. Second, in certain cases, the EEG may detect more subtle seizures, including absence, myoclonic, or partial seizures. Third, specific EEG patterns may alert the clinician to the presence of a focal cerebral lesion. Fourth, most studies have shown that an epileptiform discharge is predictive of seizure recurrence, particularly in patients with idiopathic epilepsy. In the presence of epileptiform discharge, the recurrence risk is approximately double what would be predicted after a normal EEG. The predictive value of nonepileptiform abnormal...Continue Reading

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Citations

Feb 13, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Richard J StabaGregory A Worrell
Jun 19, 2012·Expert Opinion on Drug Safety·Sheryl R HautAaron Miller
Sep 24, 2011·Neurosurgery Clinics of North America·Yu HanWentai Liu
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Jan 3, 2018·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Wendi-Jo L WendtAlexander J Rogers
Nov 9, 2018·Journal of Paediatrics and Child Health·Snehal ShahSoumya Ghosh
Jul 13, 2019·Acta neurologica Belgica·Seda DagarYunsur Cevik
Feb 5, 2014·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Nash N BoutrosJürgen Gallinat
Nov 20, 2016·Epilepsy Currents·Katherine C Nickels
Nov 23, 2017·Clinical EEG and Neuroscience·Hannah DoudouxLaurent Vercueil
Jul 3, 2020·Pediatrics in Review·Anthony Fine, Elaine C Wirrell
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Dec 29, 2020·Clinical EEG and Neuroscience·Eser BuluşSeher Naz Yeni
Feb 4, 2021·Clinical Neurophysiology Practice·Maxime O BaudVikram R Rao
Mar 5, 2021·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Karina A González OtárulaStephan Schuele
Feb 20, 2021·Journal of Taibah University Medical Sciences·Lukman F OwolabiMushabab AlGhamdi
May 18, 2021·Clinical Neurophysiology Practice·Naim HaddadZiyad Mahfoud
Jul 22, 2021·Clinical EEG and Neuroscience·Shunsuke Takagi
Aug 3, 2021·Curēus·Muhammad A KhalilyAreeba Wasim
Jun 20, 2020·Seizure : the Journal of the British Epilepsy Association·Elisabeth E M ReusFieke M E Cox

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