PMID: 7540805Mar 1, 1995Paper

Prognostic significance of keratinization in nasopharyngeal carcinoma

American Journal of Otolaryngology
S P ReddyJ E Marks

Abstract

Keratinization may be a vulnerable aid in predicting response to therapy for nasopharyngeal carcinoma. The presence or absence of keratin in biopsy specimens was correlated with tumor behavior, locoregional control, patterns of failure, and survival of patients irradiated for nasopharyngeal carcinoma. Patients with keratinizing squamous-cell cancers (World Health Organization [WHO] type 1) had a higher incidence (76%) of locally advanced tumors than those with nonkeratinizing (WHO type 2) and undifferentiated (WHO type 3) cancers (55%). The former group of patients had a lower incidence (29%) of lymph node metastases than the later group (70%). Primary tumor was controlled in 62% and neck nodes were controlled in 82% of all patients. Primary tumor control rates were 29% in patients with keratinizing squamous-cell cancers and 79% in those with nonkeratinizing and undifferentiated cancers (P = .001). Nodal control rates were 76% for keratinizing squamous-cell cancer and 85% for nonkeratinizing and undifferentiated cancers (P = .001). The incidence of distant metastases was 6% in patients with keratinizing squamous-cell cancer and 33% in those with nonkeratinizing and undifferentiated cancers (P = .001). Patients with keratinizing...Continue Reading

References

Mar 1, 1978·International Journal of Radiation Oncology, Biology, Physics·R T HoppeM A Bagshaw
Nov 1, 1989·Archives of Otolaryngology--head & Neck Surgery·H B Neel, W F Taylor
Nov 1, 1986·Journal of Surgical Oncology·A Ahmad, S Stefani
Jul 1, 1969·Cancer·C A PerezW E Powers
Apr 1, 1971·Radiology·K Y Chen, G H Fletcher
Dec 1, 1984·International Journal of Radiation Oncology, Biology, Physics·A M ChuB Jose
Apr 1, 1981·International Journal of Radiation Oncology, Biology, Physics·J B MesicH Goepfert
Jun 1, 1981·International Journal of Radiation Oncology, Biology, Physics·S Huang, G Chu
May 1, 1982·The Laryngoscope·E L ApplebaumR Haas

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Citations

Jan 1, 2005·Cancer Immunology, Immunotherapy : CII·John J L JacobsWillem Den Otter
Sep 1, 2007·Head and Neck Pathology·Lester D R Thompson
Feb 10, 2004·Gynecologic Oncology·Gabriella FerrandinaLibero Lauriola
Jun 14, 2005·Lancet·William I Wei, Jonathan S T Sham
Dec 24, 2003·Clinical Oncology : a Journal of the Royal College of Radiologists·G SanguinetiL Licitra
Jul 1, 2011·International Journal of Otolaryngology·Keiji TabuchiAkira Hara
Jun 1, 2008·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Tae Hee KimJin-Hyoung Kang
Jul 12, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y K OngE H Tan
Jun 28, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Hui ChenLianming Liao
May 10, 2002·The British Journal of Radiology·R F Mould, T H P Tai
Mar 27, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Evangelia PeponiGabriela Studer
Nov 4, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Wei-Lin TayBoon-Huat Bay
Dec 30, 2014·Radiation Oncology·Anna MerlottiUNKNOWN Italian Association of Radiation Oncology
May 20, 2011·Auris, Nasus, Larynx·Tomokazu YoshizakiKazuhira Endo
Sep 30, 2010·International Journal of Cancer. Journal International Du Cancer·Xuemei JiFuxiang Zhou
Sep 9, 2010·The Laryngoscope·Emily J LoErich M Sturgis
Apr 16, 2014·International Forum of Allergy & Rhinology·Alejandro VazquezJean Anderson Eloy
Mar 15, 2015·Seminars in Diagnostic Pathology·Fredrik Petersson
Aug 1, 1998·Japanese Journal of Cancer Research : Gann·S KojyaK Aozasa
Oct 6, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Vishal J PatelVicente A Resto
Jan 26, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J García-LorenzoX León
Sep 12, 1998·Otolaryngologic Clinics of North America·J J Brown, W E Fee
Jan 12, 2019·The Laryngoscope·Aykut A UnsalStilianos E Kountakis
Apr 10, 2010·Clinical and Experimental Otorhinolaryngology·William I Wei, Dora L W Kwong
Sep 25, 1998·The Journal of Laryngology and Otology·F RapadoR T Ramsden
May 7, 2019·Expert Review of Proteomics·Zhefeng Xiao, Zhuchu Chen

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