Prognostic significance of Ki67 evaluated by flow cytometry in dogs with high-grade B-cell lymphoma

Veterinary and Comparative Oncology
A PoggiFulvio Riondato

Abstract

Ki67 can discriminate between high- and low-grade canine lymphomas, but its prognostic role in specific subtypes of the neoplasm is unknown. We assessed the prognostic significance of Ki67% (percentage of Ki67-positive cells), evaluated by flow cytometry, in 40 dogs with high-grade B-cell lymphoma, treated with a modified Wisconsin-Madison protocol (UW-25). The following variables were investigated for association with lymphoma specific survival (LSS) and relapse free interval (RFI): Ki67%, breed, sex, age, stage, substage, complete remission (CR). By multivariate analysis, Ki67% (P = 0.009) and achievement of CR (P = 0.001) were independent prognostic factors for LSS. Dogs with intermediate Ki67% (20.1-40%) presented longer LSS and RFI (median = 866 and 428 days, respectively) than dogs with low (median = 42 days, P < 0.001; median = 159 days, P = 0.014) or high (median = 173 days, P = 0.038; median = 100 days, P = 0.126) values. Determination of Ki67 is a prognostic tool that improves the clinical usefulness of flow cytometric analysis in canine high-grade B-cell lymphoma.

References

Dec 1, 1990·Histopathology·D C Brown, K C Gatter
Aug 1, 1990·Cancer·P G GreenleeP H Lieberman
Jan 1, 1994·Acta neurochirurgica·E DonauerM Schaan
Jul 27, 1999·Veterinary Pathology·M KiupelD Bostock
Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Mar 24, 2000·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·B S PhillipsB R Madewell
Jun 6, 2000·Experimental Cell Research·E Endl, J Gerdes
Aug 24, 2001·The Journal of Small Animal Practice·J M DobsonB D Tom
Mar 21, 2002·Histopathology·D C Brown, K C Gatter
Nov 27, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·D JagielskiS Winiarczyk
Dec 6, 2002·Journal of Veterinary Internal Medicine·Laura D GarrettDavid M Vail
Jul 2, 2003·Clinical Techniques in Small Animal Practice·Susan N Ettinger
Mar 18, 2008·Journal of the American Veterinary Medical Association·Daniela SimonIngo Nolte
Apr 23, 2009·American Journal of Hematology·Adi BroydeOsnat Bairey
Feb 16, 2011·Journal of the American Veterinary Medical Association·Laura MarconatoEric Zini
Jun 1, 2013·Veterinary and Comparative Oncology·V MartiniS Comazzi
Dec 18, 2013·Veterinary and Comparative Oncology·A PoggiF Riondato

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Citations

Sep 29, 2018·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Valeria MartiniLuca Aresu
Sep 14, 2020·Veterinary and Comparative Oncology·Hiroki YamazakiHideo Akiyoshi
Dec 2, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Oscar R Sierra MatizSabryna G Calazans
Mar 27, 2021·Veterinary Pathology·Giancarlo AvallonePaola Roccabianca
Mar 25, 2021·Veterinary and Comparative Oncology·Antonella RigilloBarbara C Rütgen
Apr 20, 2021·Frontiers in Veterinary Science·Fulvio Riondato, Stefano Comazzi
May 11, 2021·Frontiers in Veterinary Science·Stefano Comazzi, Fulvio Riondato
May 18, 2021·Journal of Veterinary Internal Medicine·Emily D RoutAnne C Avery

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