Abstract
The prognostic significance of KIT mutations in core-binding factor acute myeloid leukemia (CBF-AML), including inv(16) and t(8;21) AML, is uncertain. We performed a systematic review and meta-analysis of the effect of KIT mutations on the complete remission (CR) and relapse rates and overall survival (OS) of CBF-AML. PubMed, Embase, Web of Science, and the Cochrane Library were searched and relevant studies were included. Negative effect was indicated on relapse risk of CBF-AML (RR [relative risk], 1.43; 95%CI [confidence interval], 1.20-1.70) and t(8;21) AML (RR, 1.70; 95% CI, 1.31-2.21), not on OS of CBF-AML (RR, 1.09; 95% CI, 0.97-1.23), CR (OR [odds ratio], 0.95; 95% CI, 0.52-1.74), relapse risk (RR, 1.12; 95% CI, 0.90-1.41) or OS (RR, 1.03; 95% CI, 0.90-1.18) of inv(16) AML. Subgroup analysis of t(8,21) AML showed negative effect of KIT mutations on CR (OR, 2.03; 95%CI: 1.02-4.05), relapse risk (RR, 1.89; 95%CI: 1.51-2.37) and OS (RR, 2.26; 95%CI: 1.35-3,78) of non-Caucasians, not on CR (OR, 0.61; 95%CI: 0.19-1.95) or OS (RR, 1.12; 95%CI: 0.90-1.40) of Caucasians. This study indicates KIT mutations in CBF-AML to be included in the initial routine diagnostic workup and stratification system of t(8,21) AML. Prospective larg...Continue Reading
References
May 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonM J Keating
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Aug 26, 1998·Blood Cells, Molecules & Diseases·A BeghiniL Larizza
Jul 6, 2000·Biometrics·S Duval, R Tweedie
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Feb 20, 2003·Leukemia·R CairoliE Morra
Jun 5, 2003·British Journal of Haematology·Rory S CareJohn T Reilly
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Mar 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John C ByrdClara D Bloomfield
Jul 15, 2005·Leukemia·B F GoemansM C Heinrich
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Guido MarcucciClara D Bloomfield
Oct 29, 2005·Blood·Susanne SchnittgerClaudia Schoch
Nov 18, 2005·Blood·Akira ShimadaYasuhide Hayashi
Dec 31, 2005·Blood·Roberto CairoliEnrica Morra
Apr 7, 2006·Leukemia·N BoisselUNKNOWN Leucémies Aiguës Myéloblastiques de l'Enfant (LAME) Cooperative Groups
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter PaschkaUNKNOWN Cancer and Leukemia Group B
Oct 26, 2007·Leukemia·L-Y ShihT-C Yeh
Aug 12, 2008·Seminars in Oncology·Peter Paschka
Feb 3, 2009·Haematologica·Eisaku IwanagaNorio Asou
Mar 6, 2009·PLoS Medicine·Gurdeep S SagooJulian P T Higgins
Jul 16, 2009·Leukemia & Lymphoma·Jana MarkováJirí Schwarz
Nov 3, 2009·Blood·Hartmut DöhnerUNKNOWN European LeukemiaNet
Jan 9, 2010·Blood·Jessica A PollardSoheil Meshinchi
Jan 13, 2010·British Journal of Haematology·Sonja C LückLars Bullinger
Jul 24, 2010·European Journal of Epidemiology·Andreas Stang
May 25, 2011·Leukemia·S WakitaK Inokuchi
Jul 1, 2011·Leukemia Research·Sang Hyuk ParkChan-Jeoung Park
Oct 12, 2012·Annals of Hematology·Hee-Jin KimUNKNOWN L/MDS working party, Korean Society of Hematology
Oct 31, 2012·Biochemical and Biophysical Research Communications·Di WangJianfeng Zhou
Nov 2, 2012·Blood·Peter PaschkaKonstanze Döhner
Nov 20, 2012·Blood·Sebastian SchwindUNKNOWN Alliance for Clinical Trials in Oncology
Nov 30, 2012·British Journal of Haematology·Chung H KokRichard J D'Andrea
Jan 17, 2013·Blood·Eric JourdanUNKNOWN French AML Intergroup
Mar 8, 2013·Oncology Reports·Ludovica RieraAchille Pich
Mar 27, 2013·Leukemia Research·Sang Hyuk ParkChan-Jeoung Park
Mar 29, 2013·Blood·Hong-Hu ZhuXiao-Jun Huang
Apr 27, 2013·American Journal of Hematology·Roberto CairoliEnrica Morra
May 30, 2013·Haematologica·Saiko KurosawaTakahiro Fukuda
Jun 21, 2013·Leukemia·C AllenR E Gale
Nov 15, 2013·Leukemia·E ManaraM Pigazzi
Dec 10, 2013·Hematology·Peter Paschka, Konstanze Döhner
Jan 10, 2014·Leukemia·M-T KrauthS Schnittger
Dec 3, 2014·Leukemia Research·Ya-Zhen QinXiao-Jun Huang
Citations
Jul 9, 2016·Blood Cancer Journal·C Y CherA Y H Leung
Apr 12, 2017·Current Hematologic Malignancy Reports·Cecilia C S Yeung, Jerald Radich
Aug 10, 2017·Leukemia & Lymphoma·Xi ChenLiming Bao
Jun 15, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Martin S TallmanNdiya Ogba
Nov 5, 2019·Frontiers in Oncology·Lindsay WildeJinglan Liu
Feb 25, 2020·Blood Advances·Guido MarcucciRichard A Larson
Apr 7, 2020·American Journal of Hematology·Heesun J RogersRobert P Hasserjian
Nov 22, 2017·Oncotarget·Stefano RossettiNicoletta Sacchi
Jun 7, 2019·Journal of Translational Medicine·Wen DuDong Hu
Jun 22, 2019·Drugs·Musa Yilmaz, Naval Daver
Dec 23, 2017·Frontiers in Pharmacology·Habsah AzizRahman Jamal
Oct 22, 2016·American Journal of Hematology·Ruiqi LiXianmin Song
Aug 18, 2018·Cancer Medicine·Celalettin UstunGautam Borthakur
Jul 25, 2019·International Journal of Molecular Sciences·Solène FernandezPierre-Yves Dumas
Sep 7, 2018·Medical Oncology·Tarcila Santos DatoguiaPaulo Vidal Campregher
Aug 23, 2020·Current Opinion in Oncology·Shristi Upadhyay BanskotaVijaya Raj Bhatt
Jun 12, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katherine TarlockJessica A Pollard
Jan 7, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·Daniel A PollyeaMartin S Tallman
Dec 11, 2020·Leukemia·Montserrat EstruchKim Theilgaard-Mönch
Jan 12, 2021·Frontiers in Oncology·Vanessa E Kennedy, Catherine C Smith
Jan 23, 2021·Cancers·Byung-Sik ChoHee-Je Kim
Mar 4, 2021·International Journal of Hematology·Eun-Ji ChoiUNKNOWN CoOperative Study Group A for Hematology (COSAH)
Jan 9, 2018·Leukemia Research·Stephen A StricklandAdam C Seegmiller
Jun 30, 2021·Bone Marrow Transplantation·Byung-Sik ChoHee-Je Kim